PubMed Health⌕ Search

Biomedical subjects

J Desforges

Publications and source records attributed to J Desforges.

11 recordsLinked to original sources
PubMed1999

[Prescription of hormone replacement therapy. Review on the management with abnormal mammography].

Mammography must be performed before restauring RHT. We discuss the radiological contrindications before RHT, and the predictive positive value of malignancy for stellate lesions, round opacities, diffuse microcalcifications, cluster of microcalcifications. Ultrasonography is essential for differentiating benign from malignant lesions. Diagnosis strategy (clinical follow-up, fine needle aspiration, biopsy, surgery) depends also on personal and familial history.

Biopsy, Needle↗
PubMed1990

[Pelizaeus-Merzbacher disease: the diagnostic contribution of MRI].

Pelizaeus-Merzbacher disease is a rare sex-linked leukodystrophy. Its metabolic basis has not been identified yet and diagnosis in mainly based on clinical findings and pathological investigation. Cerebral biopsy is not always performed because of lack of available therapy. Genetic counseling can be provided if the diagnosis is secured. Four cases are reported, in children with characteristic signs, who underwent magnetic resonance (MR) Imaging. MR Imaging appears to be more sensitive than computed tomography to visualize white matter disease: T1 weighted images suggest hypomyelination, in conformity with abnormal myelination. T2 weighted images show a non specific high signal in the white matter.

Brain↗
PubMed1987

The predictive value of in-vitro techniques in acute non-lymphocytic leukemia.

Bone marrow aspirates obtained from 27 patients with acute non-lymphocytic leukemia (ANLL) was cultured at the time of presentation, during remission and at relapse. Growth patterns were assessed throughout the patient's clinical course. The percentage of Ia-positive progenitor cells was assayed by a complement-dependent cytotoxicity assay. The percentage of cells in S phase was measured by a tritiated thymidine suicide index. Growth patterns of leukemic bone marrow samples at presentation showed varied numbers of clusters but only rare colonies. This was not predictive of clinical course. Growth patterns of bone marrow in complete remission from ANLL often had depressed colony numbers. However, some patients in remission had bone marrow growth patterns that approached or reached normal colony numbers, suggesting elimination of residual leukemia. The percentage of cells that expressed Ia antigen at presentation, during remission and at relapse varied widely and was not predictive of long-term remission or early relapse. The percentage of cells in S phase was also highly variable and not predictive of clinical course. At presentation the S-phase percentage correlated with the percentage of cells expressing Ia antigen. However, there was no such correlation during remission.

Acute Disease↗
PubMed1986

Splenic irradiation in the treatment of patients with chronic myelogenous leukemia or myelofibrosis with myeloid metaplasia. Results of daily and intermittent fractionation with and without concomitant hydroxyurea.

Seventeen patients with either chronic myelogenous leukemia (CML) or myelofibrosis with myeloid metaplasia (MMM) received 24 courses of splenic irradiation at this institution from 1973 to 1982. Eleven of the 17 patients had received prior chemotherapy. Patients were treated with 60Co gamma rays or 6 MV photons. The fraction size ranged from 15 to 100 rad and the total dose per treatment course from 15 to 650 rad, with the exception of one patient who received 1650 rad. Fourteen of 19 courses (71%) given for splenic pain yielded significant subjective relief while 17 of 26 courses given for splenomegaly obtained at least 50% regression of splenic size. Blood counts were carefully monitored before each treatment to limit hematologic toxicity. From this experience, the authors conclude that splenic irradiation effectively palliates splenic pain and reverses splenomegaly in the majority of patients with CML and MMM. Intermittent fractionation (twice or thrice weekly) is more convenient for the patient, appears to be as effective as daily treatment, and may be associated with less hematologic toxicity. Preliminary results of concurrent treatment with splenic irradiation and oral hydroxyurea show promise and warrant further study.

Adult↗
PubMed1985

Cytosine-arabinoside-induced colitis and peritonitis: nonoperative management.

Cytosine arabinoside is known to cause severe gastrointestinal side effects in an already very ill patient population. Three cases are reviewed in which apparent surgical peritonitis was managed conservatively, with very careful clinical monitoring. Two of the patients recovered completely, and one died of systemic fungal infection. No patient had a surgically remediable condition, and all were extremely poor surgical risks. A review of our experience and the literature leads us to recommend careful conservative management in patients receiving cytosine arabinoside who appear to have a "surgical abdomen," but in whom a definitive surgical diagnosis cannot be made.

Abdomen↗
PubMed1983

[Apropos of a case of thyrotoxic periodic paralysis (TPP): electromyographic study (EMG)].

The authors report on a case of thyrotoxic periodic paralysis characterized by attacks of flaccid tetraplegia with hypokalemia in a patient with Basedow disease, the cure of which led to the disappearance of the neurological symptomatology. The EMG investigations, performed in the course of a spontaneous paralytic attack, showed the same abnormalities as in the few similar published cases: discordance between the rich interferential recordings and the weakness of the movements; low amplitude of the electrodetection tracings; reduced amplitude of the evoked muscle action potentials on nerve stimulation. These myogenic patterns are related to the aspect of the muscle biopsy which, when performed during the paralytic phase, shows a vacuolization of the muscular fibers. The pathophysiological underlying mechanisms of the thyrotoxic periodic paralysis still remain hypothetic.

Adult↗