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J Dialdas

Publications and source records attributed to J Dialdas.

5 recordsLinked to original sources

Placental site trophoblastic tumor (trophoblastic pseudotumor) of the uterus with metastases and fatal outcome. Clinical and autopsy observations of a case.

A 41-year-old woman who 5 years earlier had a hysterectomy for a placental site trophoblastic tumor (formerly called trophoblastic pseudotumor) was readmitted to the hospital with pelvic recurrence and multiple lung metastases. Despite an initial decrease in the size of the lung metastases and concomitant lowering of the serum values of human chorionic gonadotropin (beta-HCG) from 2,200 to 40 ng/ml, combined chemotherapy became ineffective. The patient died 4 months later with widespread metastases. The clinical course and the autopsy findings of this case are reported and compared with the two similar cases reported in the literature.

Adult↗

[Circulating antibody complexes and cancer].

Circulating immune complexes (CIC) have been studied in one or several serum samples obtained from 249 patients with cancer. 42.4% of patients with evolutive tumors and 26.9% of patients in complete remission have elevated levels of CIC. It appears that, in approximately one case out of 3, the presence of CIC is not necessarily in relationship with the tumor, but could be the consequence of other clinical factors. In some instances, repeated plasmapheresis results in decreased CIC levels. The specificity of the antibodies present in CIC is not yet known.

Antibody Specificity↗

[Possibilities and limitations of immunotherapy in the treatment of malignant neoplasms].

The goal of cancer immunotherapy is to achieve cure when the more usual means of treatment fail to do so. This can be achieved in some animal models where tumor rejection antigens have been demonstrated. In man, the contribution of immunotherapy to the treatment of minimal residual but disseminated disease has been exceedingly poor. This discrepancy should be analyzed, in an effort to detect and define in vitro putative tumor rejection antigens in human tumors.

Antigens, Neoplasm↗