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Biomedical subjects

J Doherty

Publications and source records attributed to J Doherty.

48 records · Page 3Linked to original sources
PubMed1985

Empirical assessment of identity in anorexia and bulimia nervosa.

Researchers have neglected the study of the self concept of individuals who develop anorexia and bulimia nervosa. Towards rectifying this situation, Identity Structure Analysis (ISA) is introduced as an appropriate framework allowing the specification and empirical testing of postulates regarding disturbed identity development in anorexic disorders. The data presented distinguish a common constellation of identity characteristics in those suffering from anorexia and bulimia nervosa that differentiate them from normal and psychiatric control groups. Their identity pattern tends to be anti-developmental and in a state of 'identity crisis', in which identification conflicts with the maternal metaperspective of self (me as my mother sees me) are especially significant. Further analysis suggest that anorexics are in a phase of 'plummeting' identity crisis, whilst the patients in the sample with bulimia nervosa are in a 'sustained' phase. Future directions for research are noted.

Anorexia Nervosa↗
PubMed1983

Hip dislocation in cerebral palsy: selection for treatment.

Forty-five patients with cerebral palsy hip-dislocation were reviewed and it was found that some did well without treatment. For patients with hip pain, the best results were obtained with extensive resection arthroplasty: soft-tissue surgery alone was unsuccessful. Open reduction with femoral osteotomy achieved concentric reduction in all 15 patients who had this type of surgery: however, most retained their abnormal postural reflex activity to such a degree that subsequent scoliosis, pelvic obliquity, hip extension contractures and knee flexion deformities compromised the success of the hip surgery.

Adolescent↗
PubMed1977

Lysergic acid diethylamide: evidence for stimulation of pituitary dopamine receptors.

Lysergic acid diethylamide (LSD), 0.05 mg/kg and 0.20 mg/kg, significantly decreased plasma prolactin (PRL) levels in male rats. LSD, 0.20 mg/kg, also inhibits the increase in plasma PRL levels produced by chlorpromazine (CPZ), 5 mg/kg, and alpha-methyl-paratyrosine (AMPT), 50 mg/kg, both of which interfere with dopaminergic inhibition of PRL secretion. LSD was more potent than methysergide, a serotonin receptor blocker, in lowering plasma PRL levels and more potent than apomorphine, a known direct acting dopamine agonist, in blocking the increase in plasma PRL produced by quipazine, a 5-HT agonist. These results suggest LSD has potent dopamine agonist properties on the rat pituitary or hypothalamic dopamine receptors which directly or indirectly inhibit PRL secretion.

Animals↗
PubMed1971

Repression of the overproduction of porphyrin precursors in acute intermittent porphyria by intravenous infusions of hematin.

In a patient with a severe attack of acute intermittent porphyria, hematin given intravenously caused marked diminution of serum delta-aminolevulinic acid and porphobilinogen. The decline of aminolevulinate was more rapid than that of porphobilinoge. After 2 days of hematin administration, about 5 days were required for delta-aminolevulinic acid, and 11 days for porphobilinogen to return to the concentrations that were detected before treatment. Urinary excretion of both compounds also decreased after hematin administration. Considerable amounts of porphobilinogen were also found in the cerebrospinal fluid of the patient.

Adult↗
PubMedDate not supplied

Differential uptake of tritiated digoxin in benign and malignant central nervous system neoplasms.

The purpose of this study was to measure uptake of tritiated digoxin by neoplastic tissues known to have differential contents of sodium-potassium adenosine triphosphatase (Na + K + ATPase), the presumed receptor for digoxin. Tumor samples were removed at the time of craniotomy in seven patients with meningiomas (Group 1) and seven patients with more malignant central nervous system tumors (Group 2) (three astrocytomas, three glioblastomas, one meduloblastoma). Patients with meningiomas were found to have a significantly higher digoxin uptake (21.8 +/- 7.3 ng/gm tumor versus 5.7 +/- 5.2 ng/gm tumor; (p less than 0.01) and a significantly greater tissue/serum ratio (13.9 +/- 11.7 versus 3.26 +/- 3.7, p less than 0.0). This study provides the first demonstration of increased uptake of digoxin by noncardiac pathologic tissues. The results are most likely due to differences in the number of digoxin receptor sites.

Adenosine Triphosphatases↗
PubMedDate not supplied

The effect of dietary pectin on rapid catch-up weight gain and urea kinetics in children recovering from severe undernutrition.

The rates of weight gain and urea kinetics were measured in 12 children receiving one of two energy dense, isonitrogenous formulae (711 kJ/kg/day, 170 kcal/kg/day) during recovery from severe undernutrition. Both formulations contained added arachis oil but in one a source of complex carbohydrate was added in the form of pectin (3.4% of total energy). The children taking the pectin diet had a rate of weight gain which was highly significantly less (7 g/kg/day) than the children not receiving pectin (14 g/kg/day). Urea production was significantly less on the pectin diet (0.37 +/- 0.07 vs 0.55 +/- 0.18 gN/kg/day). On the pectin diet there was a reduction in the rate of excretion of urea in urine and in the rate at which urea nitrogen was salvaged by the lower bowel, but these differences failed to reach statistical significance.

Ammonia↗