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Biomedical subjects

J Dommisse

Publications and source records attributed to J Dommisse.

At least 19 recordsLinked to original sources
PubMed1998

A randomised controlled trial of intravenous magnesium sulphate versus placebo in the management of women with severe pre-eclampsia.

OBJECTIVE: To determine whether the administration of prophylactic intravenous magnesium sulphate reduces the occurrence of eclampsia in women with severe pre-eclampsia. DESIGN: Randomised controlled trial. SETTING: A tertiary referral obstetric unit. POPULATION: Eight hundred and twenty-two women with severe pre-eclampsia requiring termination of pregnancy by induction of labour or caesarean section. METHODS: The women were randomised to receive either placebo (saline) or magnesium sulphate intravenously. The investigators were blinded to the contents of the pre-mixed solutions. MAIN OUTCOME MEASURE: The occurrence of eclampsia in the two groups. RESULTS: The data of 699 women were evaluated. Fourteen were withdrawn after randomisation. The overall incidence of eclampsia was 1.8%. Of 345 women who received magnesium sulphate, one developed eclampsia (0.3%); in the placebo group, 11/340 women (3.2%) developed eclampsia (relative risk 0.09; 95% confidence interval 0.01-0.69; P = 0.003). CONCLUSION: The use of intravenous magnesium sulphate in the management of women with severe pre-eclampsia significantly reduced the development of eclampsia.

Abortion, Induced↗
PubMed1996

The haemodynamic and respiratory effects of intravenous nimodipine used in the treatment of eclampsia.

OBJECTIVE: To establish the antihypertensive properties of intravenous nimodipine used to treat eclamptic patients. To assess the effects of intravenous nimodipine on oxygen delivery and consumption. DESIGN: A prospective observational study. SETTING: The Maternity Centre Obstetric Intensive Care Unit, Groote Schuur Hospital. PARTICIPANTS: Four unselected patients presenting with proteinuric hypertension and seizures. METHODS: Haemodynamic observations were obtained by a radial artery catheter and right heart catheterisation with a pulmonary artery flow directed thermodilution catheter. Observations were obtained prior to and after the administration of nimodipine. RESULTS: A significant reduction in mean arterial pressure occurred in all patients after administration of nimodipine. This was due to a significant reduction in systemic vascular resistance. Neither oxygen delivery to the tissues nor peripheral oxygen consumption changed significantly during nimodipine infusion. No adverse effects related to the use of nimodipine were documented. CONCLUSIONS: Nimodipine is an effective vasodilator. There may be a role for nimodipine as a single agent for the management of eclampsia.

Adult↗
PubMed1996

Balloon valvuloplasty for severe mitral valve stenosis in pregnancy. A report of 11 cases.

Balloon valvuloplasties for severe mitral stenosis were performed on 11 pregnant patients with excellent results and no complications. The mitral valve area was increased from a mean of 0.9 cm2 to 2.1 cm2. There was no clinically significant mitral regurgitation. The pregnancies proceeded normally to delivery at or near term, with no maternal or perinatal morbidity or mortality.

Adolescent↗
PubMed1992

Placental bed biopsies in placental abruption.

OBJECTIVE: To investigate structural changes in the uteroplacental blood vessels in association with placental abruption. DESIGN: Prospective descriptive study. SUBJECTS: 18 women with clinical evidence of severe placental abruption delivered by caesarean section. INTERVENTIONS: Placental bed biopsies were obtained at caesarean section and studied histologically. RESULTS: Six specimens did not include trophoblast in the myometrium and were therefore not representative of the placental bed. Of the 12 representative specimens, seven demonstrated absence of physiological transformation of the utero-placental arteries (four of these were from hypertensive patients). Four biopsies showed abnormal vascular structures deep in the myometrium. One of these abnormal vessels included a fresh plug and extensive surrounding intramyometrial haemorrhage. CONCLUSIONS: Vascular malformations in association with placental abruption may be the result of trophoblastic invasion and could be the site of vessel rupture. Further descriptive and comparative studies are needed.

Abruptio Placentae↗