Biomedical subjects
Publications and source records attributed to J Drake.
Two patients recieving intravenous high dose methotrexate (MTX) and intracutaneous BCG injections as adjuvant treatment for osteogenic sarcoma suffered sudden cardiovascular collapse within minutes of infusion of MTX. These cases demonstrate that anaphylactic or idiosyncratic reactions to MTX and/or contaminants in these preparations do occur and that careful patient monitoring is required.
The Airflometer provides a useful index of expiratory flow rate and as such it is a worthwhile advance. It can provide an accurate index of FEV1 provided it is individually calibrated. Perhaps the only limitation is the lack of response of the instrument at low flow rates, for example, with an FEV1 of less than one litre. It is remarkably inexpensive.
Cardiorespiratory effects of ketamine and Althesin were measured in two groups of premedicated patients with cardiac disease. The drugs were given in clinically equivalent doses with a second dose administered about 10 min after induction. The first dose of ketamine caused a marked increase in systemic and pulmonary arterial pressure, heart rate, and central venous and wedge pressures and cardiac index. The first dose of Althesin caused a decrease in systemic arterial pressure, central venous pressure, cardiac index and heart work, but little change in heart rate. The second dose of induction agent was administered before the cardiorespiratory effects of the initial dose had resolved. The second dose of Althesin caused changes similar to those following the first dose, but less marked. The changes following the second dose of ketamine were opposite to those following the first dose.
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Seventy-one hearing aid users were surveyed two years after their initial fitting to determine whether they (1) wore the hearing aid(s) prescribed, (2) were satisfied with their aid(s), (3) had specific complaints about their aid(s), and (4) would recommend that a hearing-impaired friend or relative go through the same hearing aid selection process. Ninety-six percent of the respondents obtained that aid that we recommended. Eighty-eight percent were "very satisfied" or "satisfied" with the help that their aid(s) provided. Eighty-two percent would recommend that a hearing-impaired friend or relative go directly to a "hearing specialist" for assistance when selecting a hearing aid.