Biomedical subjects
Publications and source records attributed to J Drewett.
It was with some trepidation that I entered into private practice in the City of Perth, Western Australia. I had left behind a collapsing NHS style of dentistry in England, where the average high street dentist has to work increasingly harder and faster to maintain the same salary, with barely time for luxuries such as leisurely consultations with patients or experimenting with new equipment or materials.
Evidence for a presynaptic neuromodulatory effect of atrial natriuretic factor (ANF) has been obtained in rat adrenal pheochromocytoma cells (PC12), a clonal line that differentiates into adrenergic neuron-like cells when treated with nerve growth factor. ANF had no effect on basal norepinephrine (NE) release. In contrast, ANF markedly and significantly inhibited carbachol-induced NE release in a concentration-dependent manner. This result is consistent with the hypothesis that ANF may be an inhibitory neuromodulator.