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Biomedical subjects

J Duchier

Publications and source records attributed to J Duchier.

53 records · Page 3Linked to original sources
PubMed1979

[Development of an antihypertensive agent. Methodology and cost].

This schematic analysis demonstrates the great increase in the cost and time required to develop a new molecule, factors which therefore limit the development of new therapeutic methods. The patent period is shorter so that the period of commercialisation of a product by a single drug company is more and more limited. Therefore the situation may occur where the costs of development will no longer be covered. (In addition, the costs of research not leading to a marketable product have not been taken into account).

Antihypertensive Agents↗
PubMed1978

[Antialdosterones and enzymes of the adrenal gland].

With subcellular fractions of animal adrenals, the authors have looked for the effect of antialdosterones on different aspects of adrenal metabolism (steroidogenesis, some enzymes of intermediary metabolism, mitochondrial respiration). Antialdosterones act on mitochondrial respiration by inducing an uncoupling effect. Nature of this uncoupling cannot yet by precised. Antialdosterones inhibit steroidogenesis with concentrations corresponding to blood concentrations observed during treatment with these compounds. This inhibition could explain the annulation of hyperaldosteronism secondary to sodium loss and kaliemic replenishment. This enhance the interest of antialdosterones over other diuretics.

Adrenal Cortex Hormones↗
PubMed1978

[Effect of spironolactones on aldosterone synthesis and adrenal metabolism].

The authors study antialdosterones action on several enzymatic systems in subcellular fractions of animal adrenals. They report an inhibition of aldosterone synthesis located at the corticosterone 18 hydroxylation step but also at the following step of oxydation of 18 hydroxycorticosterone into aldosterone (in the duck as well as in the sheep). In contrast, these drugs do not modify the activity of several enzymes not involved in aldosterone biosynthesis. In addition, anti-aldosterones have decoupling action on mitochondrial respiration. This effect, observed by many authors on adrenal mitochondria can be considered as an illustration of competition between two electron transport chains (phosphorylative oxydation and hydroxylation) and not as a toxic effect. These in vitro results are of clinical interest as they are obtained with antialdosterones concentrations similar to that found in plasma of subjects treated with these diuretics and could explain the absence of secondary hyperaldosteronism in these subjects.

Adrenal Glands↗
PubMedDate not supplied

Monitoring and treatment of minimal residual cancer of the prostate.

In manifest prostatic carcinoma, partial and complete remissions are obtained in 14-44% of patients as judged by different sets of criteria, but in up to 61% as judged by a decrease in prostatic acid phosphatase. Moreover, this decrease is poorly correlated to that of prostatic size. Prostatic acid phosphatase is therefore considered to be a relatively non-specific tumor marker. A complete remission, i.e. a stage of minimal residual disease, is obtained in about 25% of the patients. Continued endocrine treatment involves the risk of a flare-up of the disease, which is probably small. Additionally, in minimal residual disease, prolonged maintenance treatment requires minimization of side effects. D-Trp-6-LH-RH appears to lead to less gynecomastia and thromboembolism than some other forms of adjuvant therapy.

Adenocarcinoma↗