Biomedical subjects
Publications and source records attributed to J Dudgeon.
Two brothers aged 18 and 14 years showing the features of familial exudative vitreo-retinopathy are described and the treatment of the condition discussed. Two of their cousins aged 9 and 7 1/2 years who showed the presence of congenital retinal folds are also described, and a possible link between the two conditions is postulated. The differential diagnosis is briefly discussed.
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A healthy baby boy presented with abdominal colic. He was subsequently noted to have enlarged, edematous corneas. A clinical diagnosis of developmental glaucoma was made despite ocular hypotony. Trabeculectomies were designed to include peripheral cornea. This served as a biopsy to confirm the diagnosis and as a surgical treatment for the condition. Morphological examination of the outflow system revealed findings compatible with a diagnosis of developmental glaucoma: a hypoplastic trabecular meshwork which contained an abundance of abnormal collagenous tissue in the extracellular spaces and the presence of endothelial cells overlying a continuous collagenous membrane. In the iris stroma there were numerous abnormal blood vessels, with a paucity of mural contractile cells.
Osteopetrosis should be considered in an infant with unexplained visual loss. In particular, the possibility of this diagnosis must be intimated to the radiologist involved in the investigation of the child.