Ly 11.2: a cell surface antigen that may identify murine lymphocytes susceptible to transformation by oncogenic agents.
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Animals↗
Biomedical subjects
J Dworkin
Publications and source records attributed to J Dworkin.
Functional properties of Ly 11.2 lymphocytes: a role for these cells in leukemia?
Functional studies of lymphocyte subpopulations reveal that Ly 11.2, a newly defined T cell surface antigen, is present on prothymocytes and natural killer cells, but not on suppressor T cells for antigen-specific IgE antibody responses, Ly 1+, 2-, 3- helper T cells nor on tumor-specific cytotoxic effector cells. Changes in the expression of Ly 11.2 regularly accompany leukemogenesis and are quite distinct from changes of other cell surface antigens thus far observed. After intrathymic inoculation of radiation leukemia virus (RadLV), many more Ly 11.2-positive cells are found expressing viral antigens than cells expressing other cell surface phenotypes. In addition, after RadLV inoculation, significantly more Ly 11.2-positive cells can be found in the thymus of susceptible mice than in the thymus of resistant mice. The greater availability of permissive (Ly 11.2-positive) cells in susceptible vs resistant hosts at the time when infectious virus is present may account for the shorter latency period and high leukemia incidence of susceptible vs resistant mice.
Animals↗
Automated MR imaging protocols for improved patient throughput.
The total time spent on each patient during an MR study determines patient throughput and ultimately influences MR scan charges. Actual data acquisition often represents only a small portion of this examination time. Other functions such as patient loading and unloading, positioning, coil placement, scan setup, and image reconstruction time also contribute to the total examination time. We describe a technique for creating automated imaging protocols for standard MR examinations which optimize these functions, thereby decreasing operator interventions and shortening the overall examination time. A prototype sequence for examining the larynx and neck was developed which allowed three sequential multiple slice acquisitions to be obtained in three orthogonal planes with a single operator setup step. All tuning and scan placement after this first step was done under computer control. The new sequence allowed larynx and neck studies to be performed in less than 30 min for spin echo and under 16 min for field echo instead of the 50-60 min required by previous methods. The new technique should be useful for improving patient throughput for a cariety of standardized examinations including the temporal bone, head and neck, joints, and other regions.
Computers↗
AIDS education for health care professionals in an organizational or systems context.
Traditionally, health education for practicing health professionals, as well as members of the public, focuses on the individual and relies on changing personal behavior. However, health care for persons with acquired immunodeficiency syndrome (AIDS), and members of their families, mainly is delivered within health and human services organizations. Providing AIDS education for health care professionals in an organizational or systems context shifts the focus from the individual to the group and from changing a person's behavior to offering health care professionals opportunities for interaction. In an organizational or systems approach, they can address patient care issues collectively, share interdisciplinary knowledge, identify problems of common concern, plan coordinated and integrated responses, and provide mutual support. A strategy for planning AIDS education is proposed for key administrators, supervisors, and care providers, who are the gatekeepers, opinion makers, and role models of organizations. Addressing organizational, community, and health care delivery system issues as part of an education program provides a forum for defining problems and a basis for uniting professionals and developing solutions.
Acquired Immunodeficiency Syndrome↗