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J E ADAM

Publications and source records attributed to J E ADAM.

3 recordsLinked to original sources
PubMed1965

CUTANEOUS LESIONS ASSOCIATED WITH INTERNAL MALIGNANCY.

Internal malignant tumours may stimulate the formation of tumour antigens which, by means of an antigen-antibody mechanism, can cause pruritus, ichthyosis, erythroderma, acanthosis nigricans, dermatomyositis, erythema-urticarial and vesiculo-bullous skin eruptions.Tumours may also interfere with normal immunity responses and allow various localized skin eruptions such as herpes zoster and epidermophytoses to escape their normal boundaries and become generalized.Skin malignancies may also be a sign of decreased immunoallergic response and by their presence alert the physician to search for an internal malignancy, either one associated with the skin lesion, such as a lymphoma, or an unrelated tumour.

Acanthosis Nigricans↗
PubMed1965

STRIAE AND THEIR RELATION TO TOPICAL STEROID THERAPY.

Atrophic striae have been reported to occur normally in 35% of adolescents and abnormally in a variety of medical conditions. Recently, the occurrence of striae has been observed in adults after the use of potent topical steroids with occlusion. Pre-existing striae have been found to enlarge after topical steroid therapy, even without occlusion. The mechanism of striae formation appears to be due to the action of the steroids on the dermal connective tissue and/or dermal matrix rather than to mechanical tension.

Adolescent↗