Biomedical subjects
Publications and source records attributed to J E Adam.
A 65-year-old woman presented with four autoimmune diseases. These include morphea, lichen sclerosus et atrophicus, insulin-dependent diabetes mellitus, and autoimmune thyroid disease. The relationship between morphea and lichen sclerosus et A is discussed, as is the link between these conditions and autoimmunity.
Cutaneous hypersensitivity to vitamin K1 injection has been reported once in North America. This case and most of the others in European literature have been associated with alcoholic liver disease. We report six patients who developed persistent skin hypersensitivity reactions at the site of vitamin K1 injection. These cases are the first reported to occur in liver disease associated with primary biliary cirrhosis, chronic myeloid leukemia, amyloidosis, and preeclampsia. Patch and intradermal skin tests demonstrated a hypersensitivity that seems to have an immune basis and is restricted to fat-soluble vitamin K1. This finding suggests that patients with any type of liver disease may be at risk for vitamin K hypersensitivity and that the hypersensitivity may be a marker of liver disease.
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Curettage is the most common surgical procedure carried out by dermatologists, yet the mechanics of curettage surgery are seldom described in standard textbooks or emphasized in the literature. The procedure for curettage is discussed and the mechanics of two technics, the pencil technic and the potato peeler technic, are described. The advantages of the potato peeler technic include better immobility of the lesion being curetted, more effective control of bleeding, and greater stability and increased flexibility and movement of the hand holding the curet.
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A delayed hypersensitivity type of allergic contact dermatitis was observed following exposure to certain brands of 50% cotton, 50% polyester coloured permanent-pressed sheets produced by a particular manufacturer. The dermatitis presented as an extremely pruritic follicular eczema of the body and vesicular edema of the ears and face. Patch testing excluded formalin as the allergen but suggested permanent-pressing chemicals as a possibility. Several washings of the sheets did not prevent the development of the dermatitis. The removal of sheets did not immediately result in improvement: the condition could persist for up to eight weeks after their discontinuance.
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Explore the source record for details and available documents.
Explore the source record for details and available documents.
One hundred and thirteen consecutive patients with acne were studied by qualified dermatologists during a trial of topical 10% benzoyl peroxide and 2%-5% sulfur cream. The results were considered "good" to "excellent" in both office and clinic situations. The method was remarkably free of undesirable side effects. The program has been adopted as a standard acne regimen at the dermatology clinic of the Royal Victoria Hospital, Montreal.