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Biomedical subjects

J E Barnes

Publications and source records attributed to J E Barnes.

8 recordsLinked to original sources
PubMed1992

Characteristics and control of contrast in CT.

Understanding how contrast is produced and controlled in computed tomography (CT) is essential to proper application of this modality. In the typical CT scanner, a narrow x-ray beam in the section thickness direction and an air gap in the section plane are used to reduce scatter and improve contrast. High- and low-contrast detectability of a CT scanner are important performance parameters contributing to optimal image quality. The limits of detectability of high-contrast objects (ie, spatial resolution) are affected by detector aperture size, pixel size of the image, algorithm used to reconstruct the image, and section thickness. Visibility of low-contrast objects is limited by image noise and the algorithm. Contrast in CT images can be controlled by the window level and window width settings used to display the image. These settings dictate how the actual measurements of tissue attenuation are translated into a gray-scale image. Wide window widths can be used to provide an accurate representation of bone, and narrow widths are more useful for visualizing soft tissues.

Contrast Media↗
PubMed1978

Optimization of xeroradiographic exposures.

Xeroradiographs were exposed over a range of mAs and kVp in the mammographic energy range. At each kVp, the technique yielding the widest halo also produced the greatest detectability of small aluminum specks in mammographic phantoms. As the kVp increased, the maximum halo width and number of visible specks decreased. At all kVps, the techniques yielding the widest halo furnished almost constant energy deposition in the selenium plate. This constant plate dose was correlated to patient exposure at the entrance of the breast, and the relationships between patient entrance exposure, kVp, and minumum detectable speck size were determined.

Female↗
PubMed1976

Initial comparative response to peak pions and x-rays of normal skin and underlying tissue surrounding superficial metastatic nodules.

Given the limitations of available material and methods for measuring skin response, the relative biological effectivenss (RBE) for the development and healing of skin reaction to pions in this experiment is 1.43. This is based on data obtained from a patient with malignant melanoma, in whom multiple skin nodules and the surrounding normal skin were randomized into three dose levels for pions and x-rays. The RBE for skin reaction was obtained while the skin tumor nodules appeared to regress at least as rapidly with pion therapy as with x-rays. Without benefit of adequate observation of time required for nodule regrowth, any estimate of tumor RBE is speculative.

Dose-Response Relationship, Radiation↗
PubMedDate not supplied

Stem corrections for ionization chambers.

Ionization chambers often exhibit a stem effect, caused by interactions of radiation with air near the chamber end, or with dielectric in the chamber stem or cable. These interactions contribute to the apparent measured exposure. To determine the stem efffect for several common ionization chamber systems, exposures were measured with TLD capsules placed at the center of 60Co fields of various sizes. These exposure measurements then were repeated with various ionization chamber systems, including two Victoreen R meters (25- and 100-R chambers), a Capintec 192 dosimeter with a Farmer 0.6-cm3 probe, a PTW transit dose probe, and an EG and G IC-18 probe with a Keithley 610-B electrometer. From a comparison of TLD and ionization chamber measurements of the variation in exposure rate with field size, stem corrections for the different systems were determined within 1%.

Cobalt Radioisotopes↗
PubMedDate not supplied

The Vietnam Era Twin Registry: a resource for medical research.

The Vietnam Era Twin Registry consists of 4,774 male-male twin pairs born between 1939 and 1957 with both brothers having served in the United States military during the Vietnam War. The registry was originally developed to provide the best control group for Vietnam-exposed servicemen to study the long-term health consequences of service in Vietnam. Recognizing the potential value of the registry for other areas of medical research, the Department of Veterans Affairs in 1988 opened the registry for use by both VA and non-VA investigators. The existence of centralized VA data bases for deaths and VA hospitalizations will strengthen future followup of the twins. This article describes the characteristics of the registry population and the process for accessing the registry.

Adult↗