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Biomedical subjects

J E Bock

Publications and source records attributed to J E Bock.

108 records · Page 6Linked to original sources
PubMed1976

Human placental lactogen hormone in serum from pregnant women with rhesus (anti-D) isoimmunization.

Determination of human placental lactogen hormone (HPL) was performed in 346 serum samples from 59 rhesus isoimmunized pregnant women. In all cases of fetal death-either intrauterine or in the first seven days after birth-we find a high level of HPL in maternal serum several weeks before death. All patients with normal HPL concentrations in the maternal serum, and who were treated by intrauterine transfusions, had surviving infants. If the indication for intrauterine transfusion is combined with an elevated HPL level in materal serum one must weigh the risk of the procedure against the poor prognosis for the fetus before deciding whether to intervene. Serum concentrations of human chorionic gonadotropin (HCG) and progesterone were of no clinical use, but we find a correlation between progesterone and HPL differing from the same correlation found in normal and diabetic pregnancies. A possible explanation is discussed in relation to the endoplasmic reticulum in the syncytiotrophoblast.

Blood Transfusion, Intrauterine↗
PubMed1976

Intra-uterine transfusion in the management of pregnant women with severe rhesus isoimmunization. I. Indications, technique, and complications.

Intra-uterine transfusion may be a life-saving procedure in severe cases of rhesus isoimmunization. Yet it may be technically difficult and poses a real hazard to the fetus. This material consists of 51 intra-uterine transfusions performed in 34 severe rhesus (anti-D) isoimmunized pregnant women. The selection of patients was based upon an evaluation of the severity of fetal erythroblastosis (past obstetric history, serological and amniotic fluid examinations). The major criterion for selection was the concentration of amniotic fluid bilirubin. The technique employed was based upon a fluoroscopic television control system. The most serious complications were blood-stained amniotic samples in 15% of the amniocenteses and vaginal leaking of amniotic fluid and preterm labour after the performance of the intra-uterine transfusions in 33%.

Amniocentesis↗
PubMed1976

Intra-uterine transfusion in the management of pregnant women with severe rhesus isoimmunization. II. Results and discussion.

The results of 51 intra-uterine transfusions in 34 pregnant women with severe rhesus isoimmunization are presented. The survival rate is 56%. Factors influencing the fetal and neonatal mortality are considered, e.g. the gestational age at the initial intra-uterine transfusion, the presence of fetal hydrops, and the interval from the initial intra-uterine transfusion to delivery. The difficulties of the selection procedure are emphasized and it is stated that in some cases intra-uterine transfusion should perhaps not be performed because of a predictable poor fetal prognosis. The significance of accumulating experience is discussed.

Adult↗
PubMed1976

A follow-up study of infants who received intra-uterine transfusions because of severe rhesus haemolytic disease.

The developmental characteristics of infants surviving the neonatal period after the performance of prenatal intra-uterine transfusions because of severe rhesus haemolytic disease were studied in 17 of 19 children, using the revised Denver Developmental Screening Test and a physical-neurological examination. The children ranged in age from 5 to 91 months. Two cases are reported as having retared psychomotor development. No cases of cerebral palsy were found. Among the minor abnormalities were squints, abdominal hernia and enamel defects. The results justify the use of intra-uterine transfusions in appropriately selected fetuses when combined with treatment of hyperbilirubinaemia and respiratory distress during the neonatal period.

Auditory Perception↗
PubMed1976

Prenatal diagnosis of soft-tissue malformations by ultrasound and X-ray.

This study presents four cases of fetal soft-tissue malformations diagnosed during pregnancy by ultrasonic scanning and amniography. The series comprises two fetal teratomas, one case of fetal ascites, and one case of a partial mole with coexistent fetus. Diagnostic and differential diagnostic problems are illustrated by a fifth case where the final diagnosis was a big maternal ovarian cyst-adenoma coexistent with a normal fetus.

Adult↗
PubMedDate not supplied

Prevalence of human papillomavirus types 11, 16 and 18 in cervical swabs. A study of 1362 pregnant women.

Cervical smears from 1362 pregnant women were examined by filter in situ hybridisation for human papillomavirus (HPV) types 11, 16 and 18. 119 women (8.7%) had HPV-positive smears, HPV 16 being the most common type (61% of all infections). There was a correlation with age (r = 0.63, p = 0.004), the highest incidence found in women less than 22 years old with a decline after the age of 30. The incidence of cervical HPV infection was significantly higher (20.3%, p less than 0.01) in the subgroup of women with past or present vulvar condyloma, but not in women with previous pelvic inflammatory disease or genital herpes. In 18 women with current dysplasia the smears harboured HPV 16, 18, or both in eight cases (40%). The incidence of HPV infection in 71 women with earlier dysplasia did not differ from that of the women who never had dysplasia.

Adolescent↗
PubMedDate not supplied

Filter in situ hybridisation: an evaluation of the FISH technique for HPV detection in cervical swabs.

The filter in situ hybridisation (FISH) method for detection of HPV in cervical swabs was evaluated against the Southern blot technique on concomitant cervical biopsies. Of 73 biopsies, HPV 16 DNA sequences were found in 26 biopsies and HPV 18 sequences in 2 biopsies. Analysis by FISH of the corresponding smears detected 58 and 100% of these, respectively. Of the smears corresponding to the HPV-negative biopsies, 17% were HPV 16-positive and 3% were HPV-18 positive by FISH. Re-hybridisation with cold plasmid added for competition did not change these results. To estimate the risk of spurious hybridisation between vector remnants in the probe and bacterial DNA sequences present in smears, we have hybridised by FISH to preparations of the 19 most common vaginal microorganisms. Of these, E. coli, which is present in about 10% of cervical smears, hybridised strongly with a probe of the plasmid vector pBR322 and may be a significant cause of false positive FISH results. None of the bacteria hybridised with probes of purified HPV when cold, denatured plasmid was added for competition. Analysis by FISH with probes of purified pBR322 to 167 smears of a patient control group resulted in 6% positive reactions. In hybridisations with probes of HPV 16 and 18 to 2 or 3 different filter preparations of the same smear, identical results were obtained in 18 of 19 smears, indicating a good reproducibility by the FISH method. The high percentage of HPV negative smears is equivalent to the rates known from cytology and may reflect sampling errors.

Biopsy↗