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Biomedical subjects

J E Cade

Publications and source records attributed to J E Cade.

At least 37 records · Page 2Linked to original sources
PubMed1999

Diet and lifestyle characteristics associated with dietary supplement use in women.

OBJECTIVES: To describe the characteristics of dietary supplement users in a large cohort of women and test the hypothesis that supplement users would be more likely to have a healthier lifestyle than non-users. DESIGN: Comparison of nutrient intakes from food frequency questionnaire (FFQ) data for 8409 supplement users and 5413 non-users. Use of logistic regression modelling to determine predictors of supplement use in this cohort. SUBJECTS: 13,822 subjects from the UK Women's Cohort Study (UKWCS) for whom data on supplement use was available. RESULTS: Significant differences in nutrient intakes from FFQ were seen between the two groups, with supplement users having higher intakes of all nutrients, except for fat and vitamin B12. Use of dietary supplements was associated with being vegetarian, vegan or fish-eating, consuming more fruit and vegetables, being more physically active and having a lower alcohol intake. Supplement use was less likely in those with a body mass index above 25 and those who reported smoking regularly. CONCLUSIONS: The findings are consistent with the hypothesis that supplement use is associated with a healthier lifestyle profile and an adequate nutritional intake, suggesting that supplement users do not need to take supplements to meet a nutrient deficiency.

Adult↗
PubMed1998

The sugar-fat relationship revisited: differences in consumption between men and women of varying BMI.

OBJECTIVE: To assess the relationship of dietary fat and sugar consumption in men and women with different body mass indices (BMI). To determine the actual food sources for sugar intake, comparing differences between men and women across BMI groups. The effect of excluding individuals with low energy intakes (that is, invalid data) on these relationships was also incorporated in the analysis. SUBJECTS: Subjects for this analysis were those individuals who participated in the 1986-1987 Dietary and Nutrition Survey of British Adults (DNSBA). METHOD: In the DNSBA, dietary intake was assessed using seven-day weighed food records, providing estimates of dietary fat and sugar intake. From the DNSBA database food records, sources of sugar intake were classified into five sugar containing food groups (high fat sweet products, fruits, dairy products, sugar products (excluding soft drinks) and sugar products (including soft drinks)). BMI was calculated from the measurement of height and body weight. RESULT: A positive relationship between BMI and dietary fat intake was found for men, both when fat was expressed as a percentage of energy and in absolute terms (g/d). This relationship was only replicated for women when intake was expressed in absolute terms. A negative relationship was found between sugar intake (as a percentage of energy) and BMI in men, but not women. Expressing sugar consumption in absolute terms did not produce a statistically significant relationship with BMI for either men or women. In women the only sugar source associated with BMI was high fat sweet products (for example, cakes, biscuits, chocolate), where higher intakes were related to higher BMIs. The reverse relationship was found for men. In men, BMI was also negatively related to the intake of sugar products (for example, table sugar, preserves, sugar confectionery), both when soft drinks were included and excluded. The inclusion of low energy reporters (LER) in the analysis altered the relationships between nutrients and BMI, particularly among women. The association between overall fat intake (g/d) and BMI was weakened, while the negative relationship with sugar intake was strengthened. In the case of women, the inclusion of LER completely reversed the relationship between consumption of high fat sweet foods (cakes, biscuits, chocolate) and BMI (due to the reduced reporting of these products by obese women). Fewer alterations in the relationships between BMI and the sources of sugar consumed were observed in men than in women when LER were included in the analysis. CONCLUSION: The relationships between dietary fat, sugar and BMI are different in men and women, and are dependent on the inclusion of LER, particularly in women. The results suggest that among women the consumption of high fat sweet products may be a factor in understanding obesity. Furthermore, the observation of high consumption of these foods among obese women is consistent with measured preferences for these high fat sweet foods. The altered representation of the data created by LER appears to distort the relationship between sugar, fat and the degree of obesity in men and women.

Adult↗
PubMed1996

High and low fat consumers, their macronutrient intake and body mass index: further analysis of the National Diet and Nutrition Survey of British Adults.

OBJECTIVES: To explore the different characteristics of high and low fat consumers, in particular their macronutrient intake and body mass index. DESIGN: Reanalysis of data from the Dietary and Nutritional Survey of British Adults. Comparisons were made between groups defined as high and low fat consumers on the basis of 7-day weighed food records considered to be valid for energy intake. Individuals were classified in two ways according to the percentage energy from fat (FAT%) and the absolute amount of fat consumed (FATg). The criteria for classification of the high FAT% being > 45% (high fat) and < or = 35% (low fat). For the FATg group the threshold for the high fat group was > 138 g/day (men) and > 102 g/day (women), and for the low fat group < 85 g/day (men) and < 70 g/day (women). SETTING: Dietary data was collected from private households in Great Britain between 1986 and 1987. SUBJECTS: From the total population of 2197, individuals who were slimming, ill or had an EI: BMR of < 1.2 were excluded in order to use data which was most likely to represent habitual energy intakes. From the remaining 1240 subjects, 10.8% of this sample (6.1% of the total population) were classified as low fat consumers (76 men and 58 women) and 15.4% high fat (8.7% of the total population, 93 men and 98 women). MAIN OUTCOME MEASURES: Macronutrient consumption and body mass index (BMI). RESULTS: 30% of the subjects changed fat group classification when the criteria of defining high and low fat groups altered from FAT% to FATg. Nutrient intakes differed according to definition of the groups. The high fat FATg group ate significantly more of all nutrients than the low fat FATg group. However, this was not seen for the FAT% analysis, with the high fat group eating more fat and less carbohydrate. The average BMI tended to be higher in the high fat than the low fat groups, particularly in the FATg analysis. However, the high fat group contained a wide range of BMIs. Further exploration of BMI in the high fat groups, showed that age (an 11-year difference) was the only variable to distinguish individuals in the top and bottom quartiles of BMI. CONCLUSIONS: High and low fat consumers differ according to a number of variables, and this is affected by how these groups are defined (FAT% or FATg). High fat consumers tend to have a higher BMI than low fat consumers, but not all high fat consumers are overweight or obese.

Adult↗
PubMed1995

Presence of anti-hepatitis C virus serum markers in a dental school patient population.

Hepatitis C virus (HCV) has joined the list of infections liver diseases of which the practicing dentist must be aware. This recently described RNA virus causes between 20% to 40% of reported cases of viral hepatitis in the United States. Patients with HCV show symptoms only one quarter of the time, but chronicity is maintained longer than with the other liver infections. The major mode of transmission is percutaneous, so dentists are potentially at risk to contact the virus. To assess the presence of exposure to HCV, a total of 500 dental school patients were screened for serum antibody to this virus (second-generation anti-HCV). In addition, participants were required to fill out a special screening questionnaire designed to indicate high-risk groups. Their serum was also analyzed for serum chemistries known to be associated with acute and chronic liver disease. Analysis of the 15 response questionnaires revealed statistical significance relating to questions inquiring about previous exposure to blood (transfusions, surgical procedures, etc) but little significance relating to lifestyle. In either case responses were not of practical predictive value. More than 5% of our sample patients were found to be positive reactors to anti-HCV, indicating previous HCV exposure. A significant number of those positive for anti-HCV also showed elevation of serum chemistries associated with hepatitis.

Adolescent↗
PubMed1994

HIV-1 antibody positive hepatitis B surface antigen serum in a dental school patient population.

Testing for human immunodeficiency virus antibody (anti-HIV-1) in patients positive for hepatitis B surface antigen has never been performed in a dental school patient population. In this population there was a 2.8% positive reactivity for HIV-1 antibodies in subjects who were also positive for hepatitis B surface antigen. An enzyme-linked immunoassay with a repeat test and confirmation with a Western blot technique were used.

Blotting, Western↗
PubMed1994

Cancer education curriculum at the Louisiana State University School of Dentistry.

The cancer education curriculum at Louisiana State University School of Dentistry provides students didactic and experiential learning throughout their dental training. Freshman are presented concepts of early detection of cancer in an oral diagnosis course. Later courses in oral diagnosis, medicine, and pathology include diagnostic and treatment decision making and rehabilitative information. Junior students attend a head-and-neck-tumor board composed of dentists and physicians that decides cancer treatment and rehabilitation. Juniors also participate in a biopsy service that includes observing or performing the biopsy, examining the tissue microscopically, and reporting their findings. Additionally, a required, medical and dental, multidisciplinary course in oral oncology provides instruction in diagnosis, treatment, and rehabilitation of cancer patients. Seniors participate in an oral cancer screening service as part of their community dentistry rotation. The postgraduate dental programs and the dental hygiene programs also participate in this curriculum.

Biopsy↗
PubMed1991

Relationship between diet and smoking--is the diet of smokers different?

STUDY OBJECTIVE: The aim was to compare nutrient intakes of smokers, past smokers, and non-smokers. DESIGN: The study was cross sectional and compared nutrient intake by smoking status using data obtained from a concurrent study of diet. SETTING: The study took place in three towns in England: Ipswich, Wakefield, and Stoke on Trent. PARTICIPANTS: Food records were obtained from 1115 men and 1225 women aged 35 to 54 years, representing response rates of 84-86% in the three towns. MEASUREMENTS AND MAIN RESULTS: Diet was assessed using a 24h food record in household measures. For both men and women vitamin C, total fibre, beta carotene, and vitamin E intakes were lowest in the current smokers and highest in the non-smokers with past smokers having intermediate values. Polyunsaturated/saturated fat ratio was lowest in the current smokers. Men who smoked had higher energy intakes than those who did not. The lower fat intakes of beta carotene, vitamin C, fibre, and polyunsaturated fat in the smokers was due to fewer smokers eating a whole range of foods including fruit, wholemeal bread, cereals, and polyunsaturated margarine. Current smokers had a lower body mass index than non-smokers or past smokers despite their higher energy intakes. CONCLUSIONS: Smokers have different nutrient and food intakes compared with past smokers or non-smokers.

Body Mass Index↗
PubMed1989

Comparison of a food frequency questionnaire with a diet record.

The associations between levels of nutrients derived from a 24-hour diet record and a food frequency questionnaire were assessed in a sample of 433 men and women. The food frequency questionnaire was administered three years after the completion of the diet record. Spearman correlations were all statistically significant; they varied from 0.36 for energy to 0.15 for vitamin A. Comparison of distributions into fifths showed few people grossly misclassified. A model was developed to assess the correlations which would be expected under various conditions of within and between subject variance for each nutrient, errors in measurements and drift in intake over time. The best possible correlation that could be obtained using the within and between subject variations in intake previously published, and with no measurement error or drift over time, was 0.60 for energy and 0.34 for vitamin A. Using a realistic measure of measurement error (standard deviation on log scale of 0.12 for diet record method, 0.06 for drift over time and 0.18 for food frequency method) the correlations obtained in the modelling were very similar to that observed. This study shows that it may be appropriate to use a food frequency questionnaire instead of a diet record to estimate intakes in population based epidemiological studies.

Adult↗
PubMed1988

Diet and inequalities in health in three English towns.

The diets of 2340 middle aged men and women living in three English towns were recorded. Consumption of fat and the other main nutrients was lowest in the northern industrial town, which had the highest death rates from ischaemic heart disease and from all causes combined. The findings suggest that differences in diet in middle age are not a major cause of differences in adult mortality between one part of Britain and another.

Breast Neoplasms↗
PubMed1988

Nutrient sources in the English diet: quantitative data from three English towns.

Diet records from 2402 middle-aged men and women in three English towns have been used to derive food lists which indicate the percentage contribution each food, or group of foods, makes to the intake of specific nutrients. Comparison of these food lists with those based on the American diet show differences in sources of nutrients; for example, brussels sprouts provide 5% of the vitamin C intake in our English towns, whereas in the US they provide only 0.3%. It would not be appropriate, therefore, to use American food lists in English populations, since important sources of the nutrient may be omitted or non-important sources included. These food lists can be used for English populations as a basis for food frequency questionnaires.

Diet Surveys↗
PubMed1986

Malignant fibrous histiocytoma in the maxilla: review of literature and report of a case.

This case report demonstrates the difficulty involved in establishing a diagnosis of malignant fibrous histiocytoma. The histologic characteristics of this tumor as well as the important contributions of electron microscopy and special staining techniques in making the diagnosis, have been discussed. Review of 16 cases of MFH revealed the typical presentation of maxillary sinus malignancy. Treatment modalities vary, depending on the size of the tumor and the preference of the surgeon.

Adult↗