Biomedical subjects

J E Cairns

Publications and source records attributed to J E Cairns.

At least 19 recordsLinked to original sources

PubMed1985

Clear-cornea trabeculectomy.

In most reported series of trabeculectomy results a failure rate of 10 to 15 per cent is quoted. It seems likely that some, perhaps the majority of these failures are due to conjunctival or tenon scarring. If a method of trabeculectomy could be devised so that the conjunctiva and tenon's capsule were not injured, the failure rate might be reduced. The clear-cornea approach has been developed with this in mind. The rational basis, the surgical method and results in a small number of cases will be described.

Cornea↗

PubMed1983

Experience with the Molteno long tube implant.

Dissatisfaction with other forms of treatment in the neovascular and other 'difficult' glaucomas led the authors to use the Molteno long tube implant. This paper resulted from a review of the results obtained in 30 cases over the past four years. The patients fell naturally into the two groups of neovascular and non-neovascular glaucomas. The eyes with neovascular glaucoma had an implant used early in the disease process, while the eyes with non-neovascular glaucoma tended to have the implant used as a last resort, after the failure of conventional techniques. An overall success rate of 63 per cent was found and this could be subdivided into success rates of 50 per cent for the non-neovascular group and of 75 per cent for the neovascular group. These findings probably reflect the late or early use of the implant in the disease process. The results confirm the authors' clinical impression that the Molteno long tube implant is a useful tool in the management of these glaucomas, and that for optimal results it should be considered early in the condition.

Adolescent↗

PubMed1983

The Molteno long-tube implant.

The surgical treatment of open angle glaucoma in eyes expected to have an unsuccessful result from trabeculectomy is considered. It is concluded that the long-tube implant of Molteno is currently the method of choice. The rationale of the method is discussed. The technique is described.

Drainage↗

PubMed1981

Rationale for therapy in neovascular glaucoma.

The pathological physiology of neovascular glaucoma is discussed. Various methods of treatment are examined in the light of the theory of causation. The conclusion is drawn that drainage surgery is the most promising of the alternatives. Since conventional drainage surgery is not effective, it is suggested that the long-tube implant of Molteno is the treatment of choice. Results and complications in ten cases are presented.

Atropine↗

PubMed1976

Goniospasis: a method designed to relieve canalicular blockade in primary open-angle glaucoma.

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Aged↗

PubMed1975

Glaucoma.

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Glaucoma↗

PubMed1974

[Goniospasis, a method designed to relieve canalicular blockade in primary open-angle glaucoma (author's transl)].

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Aged↗

PubMed1973

Iridocyclo-retraction in glaucoma secondary to essential iris atrophy.

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Atrophy↗

PubMed1972

Temperature-sensitive mutants of vesicular stomatitis virus: in vitro studies of virion-associated polymerase.

The temperature dependence of the virion-associated polymerase activity of six temperature-sensitive (ts) mutants of vesicular stomatitis virus (tsW10, 11, 14, 16B, 28, and 29) has been examined in vitro and compared to the heat-resistant parent (HR). The polymerase of five of the mutants (tsW10, 11, 14, 16B, and 28) appears to be significantly more ts than that of HR. Because certain pairs of these five mutants can complement each other's in vitro polymerase activity, it appears that in vitro some components involved in the polymerase of one virion can be utilized by another virion. Examination of 19 revertants of tsW11 and tsW16B which had regained their ability to replicate at 38 C showed that their in vitro polymerase activity had also become less ts. Furthermore, it was found that the pairs of mutants which showed in vitro complementation of polymerase activity at 38 C were those which had shown complementation in yielding infectious progeny in mixedly infected cells. These two observations suggest that the ts behavior of the in vitro polymerase activity of the five mutants is related to their inability to replicate at the nonpermissive temperature.

Animals↗

PubMed1972