Biomedical subjects
Publications and source records attributed to J E Carbone.
A case of bilateral compression femoral neuropathy due to iliopsoas muscle hematomas during anticoagulant therapy is described. Diagnosis was confirmed with computed tomographic scan. The right hematoma was larger than the left and caused a more severe femoral neuropathy. The hematoma on the right side was surgically evacuated, and the left-sided one was treated conservatively. The patient had a complete recovery.
Obstructive sleep apnea (OSA) occurs in patients with narrowing of the pharyngeal airway due to a variety of pathologic conditions. We documented obstructive and mixed sleep apnea in a patient with narrowing of the airway caused by macroglossia associated with amyloidosis. Tracheostomy relieved the symptoms of OSA (hypersomnolence, confusion upon awakening, and hyperkinesis during sleep) despite the emergence of striking central sleep apnea following the procedure.
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To evaluate the effects of air warming and humidification, we examined the spirometric responses before and after exposure to a conditioned airsteam. Seven healthy subjects, seven clinically stable patients with chronic bronchitis and seven clinically stable asthmatic patients were studied during quiet breathing. All were exposed to the following air conditions for ten minutes: -20 degrees C, dry; 37 degrees C, dry; 37 degrees C, fully saturated; 50 degrees C, dry, and 50 degrees C, fully saturated. As heat increased, airflow progressively improved in asthmatic persons as a group. In contrast, patients with chronic bronchitis, who had more severe underlying airflow obstruction, had most improved airflow with warm dry air inhalation and showed less improvement as humidity was added isothermally. We conclude that active warming of air before inhalation can improve airflow significantly in some patients with reactive obstructed airways, and that high degrees of humidity may exert an independent adverse effect in persons with chronic bronchitis or in those with serious airflow obstruction.
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