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Biomedical subjects

J E Cox

Publications and source records attributed to J E Cox.

At least 91 records · Page 5Linked to original sources
PubMed1975

Suprapubic paramedian laparotomy for equine abdominal cryptorchidism.

The history of techniques for abdominal equine cryptorchidectomy is briefly reviewed. The technique of suprapubic paramedian laparotomy as used since 1955 at the University of Liverpool veterinary field station is described in detail and an account given of the authors' experience with the technique in nearly 200 cases. It is concluded that the approach to the abdominal cavity is easy, that the testis itself is generally readily located and removed and that controlled repair of the incision is possible. Serious post-operative complications are rare and the danger of post-operative prolapse of bowel eliminated.

Anesthesia, Intravenous↗
PubMed1975

Oestrone and equilin in the plasma of the pregnant mare.

A method for the extraction of oestrone and equilin from the plasma of the pregnant mare is described, and the levels obtained for eighty-two samples from fourteen Welsh Mountain Ponies at different stages of pregnancy are recorded. Oestrone (fifteen samples) and equilin (three samples) were not found before Day 120. From Day 120 to 240, oestrone levels exceeded 100 ng/ml and then declined to parturition. The high concentrations of oestrone in mid-pregnancy were associated with gradually increasing concentrations of equilin which tended to plateau after Day 180 at just under 100 ng/ml and declined significantly only in the last month of pregnancy. Evidence is presented that both oestrone and equilin occur in peripheral plasma largely as sulphates.

17-Ketosteroids↗
PubMedDate not supplied

Gastric adenocarcinoma in a patient with common variable immunodeficiency.

We describe a 46-year-old man with a 20-year history of common variable immunodeficiency (CVID) who developed adenocarcinoma of the stomach. Although the mechanism is still debated, there is an increased frequency of gastric adenocarcinoma of the stomach in patients with CVID. Consequently, gastric complaints in patients with CVID should be pursued aggressively.

Adenocarcinoma↗
PubMedDate not supplied

Dose-dependent interaction between cholecystokinin and sham feeding.

Previous work in this laboratory indicated that decreases in feeding motivation produced by cholecystokinin octapeptide (CCK-8) develop through synergism with signals generated by feeding. In these experiments, we used a runway paradigm to assess the contribution of signals from the oral cavity to this interaction. In contrast to the substantial (44%) impairment in runway performance produced by the combination of 1 microgram/kg CCK-8 and 5 min normal prefeeding, 5 min sham feeding failed to potentiate the effect of 1 microgram/kg CCK-8. Sham feeding in conjunction with this dose of CCK-8 reduced running speed by no more (2%) than CCK-8 alone (9%). Similar results were obtained whether rats were allowed a longer sham feeding interval (12 min) or the prefeeding interval was shifted in time so that it ended only 3 min before the start of the runway test. By contrast, larger doses of CCK-8 interacted with 5 min sham feeding to substantially impair runway performance; significant decreases in speed of 29% and 41% were observed after 2 and 4 micrograms/kg CCK-8, respectively. Results with these doses indicate that synergy between CCK-8 and signals from the oral cavity can contribute to the inhibitory effects of this agent. However, the failure of the combination of the 1 microgram/kg dose and sham feeding to replicate the interaction seen with normal prefeeding indicates the additional involvement of signals arising from food stimulation distal to the oropharynx.

Animals↗
PubMedDate not supplied

Supercritical fluid extraction in the determination of tobacco-specific N-nitrosamines in smokeless tobacco.

A new approach to the analysis of the carcinogenic, tobacco-specific N-nitrosamines (TSNA) in moist snuff tobacco is based on the extraction of tobacco with methanol-modified supercritical carbon dioxide. Extracted TSNA are trapped across a glass cartridge filled with Tenax GR, from which they are subsequently released by thermal desorption and analyzed by capillary gas chromatography with a thermal energy analyzer. The analytical recoveries for the major TSNA range from 83 to 98%; the detection limits are below 2 ng/g. The methodology is fast, reproducible, highly selective, and sensitive. The supercritical fluid extraction (SFE) releases up to 7 times more of the highly carcinogenic 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) from tobacco than has been determined after conventional solvent extraction. Studies have confirmed that this is not an artifact. In contrast, the cyclic N-nitrosamines, N'-nitrosonornicotine, N'-nitrosoanabasine, and N'-nitrosoanatabine, showed no significant quantitative differences whether determined by the SFE method or the conventional solvent extraction method.

Carbon Dioxide↗