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Biomedical subjects

J E Fulton

Publications and source records attributed to J E Fulton.

At least 19 recordsLinked to original sources
PubMed1991

The prevention and management of postdermabrasion complications.

The complications of keloids, pigment changes, loss of skin texture, and enlarged facial pores remain a problem with dermabrasion patients. Their occurrence can be reduced by proper patient selection, proper dermabrasion technique, proper wound management, and prompt treatment. Keloids are rapidly resolved with the use of flurandrenolide tape covered with positive-pressure chin-strap dressings. Streaks of hyperpigmentation are lightened with a combination of sunscreen, opaque makeup, tretinoin, and hydroquinone lotions. The loss of skin texture can be prevented by not abrading too deeply and avoiding subsequent bacterial contamination during wound healing. However, enlarged skin pores in the central portion of the face and hypopigmentation can be permanent complications.

Dermabrasion↗
PubMed1990

Chicken A blood groups system antigens: molecular characteristics and lack of expression on lymphocytes.

The molecular structure of two antigens (A2 and A4) of the chicken A blood group system was determined by using an A4-specific monoclonal antibody (ISU-cA) and several alloantisera specific for chicken A blood group antigens. Molecules immunoprecipitated from erythrocytes were separated on sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE) under either reducing or non-reducing conditions. Molecules of relative molecular weights 53.0 and 54.5 Kd were identified under reducing conditions for A2 and A4 antigens, respectively, and non-reduced molecules had a relative molecular weight of 44.5 Kd for both antigens. Two-dimensional electrophoresis showed a similar, single, diffuse band near pH 6.5 for each antigen. The data are consistent with a glycosylated molecule with one or more intrachain disulphide bonds. Allelic differences between A2 and A4 antigens seem to be due to an additional moiety on A4 antigen with a net neutral charge. Binding to chicken lymphocytes of antibody specific for A antigens was not detected by enzyme-linked immunosorbent assay (ELISA). Immunoprecipitations of radiolabelled peripheral blood lymphocyte-surface molecules using ISU-cA and A-specific alloantisera also did not detect A blood group antigens. Thus, chicken A blood group antigens are not indicated to be present on lymphocytes.

Animals↗
PubMed1990

Monoclonal antibody differentiates chicken A system alloantigens.

A monoclonal antibody (ISU-cA) was produced that recognized certain alloantigens of the chicken A blood group locus. Antigens produced by alleles A3, A4 and A8 were positive, and those produced by A2 and A5 were negative, by haemagglutination. The specificity of ISU-cA for chicken A blood group antigens was demonstrated by serologic analyses, genetic crosses and competitive inhibition of binding by anti-A alloantisera. To our knowledge, this is the first reported monoclonal antibody against a chicken blood group alloantigen system other than the B complex.

Alleles↗
PubMed1990

Ontogeny and expression of chicken A blood group antigens.

Expression of chicken red blood cell (RBC) surface antigens was studied by using a monoclonal antibody (ISU-cA) specific for chicken A blood group antigens. Erythrocytes were examined from embryos of 3-18 days of incubation and from chicks at hatch up to 21 weeks of age. Specific antigens were detected on embryonic RBC surfaces by immunofluorescence as early as 3 days of incubation. Antigenic expression was examined by both haemagglutination and immunofluorescence and found to increase with age from embryos to mature birds. The antigen concentration on the cell surface was found to be affected by genotype; heterozygotes had an intermediate level of antigen between that of the two parental genotypes. These data confirm the co-dominance that is observed with most blood group antigens. Flow cytometric analysis allowed confirmation that the entire erythrocyte population gradually increased in antigenic expression over time, rather than having an antigen-negative subpopulation being replaced by a positive subpopulation.

Animals↗
PubMed1990

The stimulation of postdermabrasion wound healing with stabilized aloe vera gel-polyethylene oxide dressing.

Full-face dermabrasion provided an ideal opportunity to document the effects of dressings on wound healing management. Following the procedure, the abraded face was divided in half. One side was treated with the standard polyethylene oxide gel wound dressings. The other side was treated with a polyethylene oxide gel dressing saturated with stabilized aloe vera. The polyethylene oxide dressing provided an excellent matrix for the release of aloe vera gel during the initial 5 days of wound healing. By 24-48 hours there was dramatic vasoconstriction and accompanying reduction in edema on the aloe-treated side. By the third to fourth day there was less exudate and crusting at the aloe site, and by the fifth to sixth day the reepithelialization at the aloe site was complete. Overall, wound healing was approximately 72 hours faster at the aloe site. This acceleration in wound healing is important to reduce bacterial contamination, subsequent keloid formation, and/or pigmentary changes. The exact mechanism of acceleration of wound healing by aloe vera is unknown.

Aloe↗
PubMed1988

Role of anxiety and anger in acne patients: a relationship with the severity of the disorder.

Studies investigating the possible role of personality and emotional factors in acne patients have yielded inconsistent and sometimes contradictory results. In the present study acne patients self-rated the severity of their conditions as mild, moderate, or severe and were compared to a control group on several personality variables. These self-ratings were compared to the objective ratings made by their dermatologists. Acne patients who self-rated their conditions as severe were found to experience significantly higher levels of trait anxiety than patients with mild and moderate conditions and control subjects; patients with severe and moderate conditions showed a higher state of anxiety than control subjects. Acne patients rated as severe by their dermatologists showed higher states of anxiety, "anger-in," and "anger-out" than the others. No other significant differences in terms of severity emerged, supporting the view that acne patients are not markedly neurotic. The results suggest that anxiety and anger are significant factors for severe acne patients and that future research should include severity ratings from both patients and physicians in the research design.

Acne Vulgaris↗
PubMed1987

Anatomical defects associated with a feathering mutant (Ottawa naked) in domestic fowl.

An autosomal recessive mutation (Ottawa naked, nk) that causes abnormal feathering, fusion of the third and fourth toes, and low viability has been reported previously in the chicken. In the present study mutant individuals were examined from three different stocks: the original one in which the mutant was found and two outbred F2 stocks. Defects of the tail region were observed in all mutants from the original stock (20/20) and in 64% (16/25) of the mutants produced from the outcrossed stocks. The severity of the defects ranged from mild distortion and scoliosis of the coccygeal vertebrae to absence of all vertebrae from the lumbosacral level caudad. Forty percent (16/40) of the mutants from the original stock lacked caudal portions of the kidneys to varying degrees. Edematous areas were observed in 22% (15/67) of the embryos examined at 14 days of incubation. Other defects observed in the mutant embryos but not studied in detail are abnormal patterning or absence of scales, absence of the caudal spinal cord in embryos with severe rumplessness, and failure of the three metatarsal bones to fuse into a single element. Since all structures affected in the mutants differentiate primarily from or may be dependent upon the mesoderm, it is suggested that the site of gene action lies within this germ layer. A decrease was observed in both incidence and severity of the various defects following outcrossing, which suggests the presence of modifiers that influence the expression of the trait.

Animals↗
PubMed1987

Dermabrasion-Loo-punch-excision technique for the treatment of acne-induced osteoma cutis.

Three patients with chronic osteoma cutis secondary to acne vulgaris were treated with the dermabrasion-Loo-punch-excision technique. Under regional nerve block with lidocaine-bipuvacaine (50:50) a uniform dermabrasion was performed across the entire face, including the hairline and 1 cm below the jawline. This exposed the foci of osteoma cutis. Then the appropriate sized Loo punch (usually the 2.0- or the 2.5-mm punch) was used to excise the bluish-gray miliary lesions. The majority of the foci were removed in one operation. Following excision, the lesions were closed with 7-0 prolene suture. To prevent crust formation postoperatively, Aloe-vera-soaked polyethylene oxide gel dressings (Vigilon) were changed twice daily following an ice water compress. Sutures were removed rapidly in 5 to 7 days to prevent the appearance of suture lines. Although one patient required an additional procedure, the cosmetic results were excellent. Only a few small residual blue "dot" lesions remained in these three cases.

Acne Vulgaris↗
PubMed1987

Modern dermabrasion techniques: a personal appraisal.

Improvements in dermabrasion techniques have upgraded the therapeutic results for the removal of acne scars, sun-damaged skin, and related skin lesions in selected patients. To help patient compliance and therapeutic response, and to avoid pitfalls, extensive step-by-step predermabrasion evaluation and patient selection procedures are helpful. Standard checklists, operative techniques, and patient follow-up procedures have improved the results. Currently, the optimal dermabrasion procedure consists not only of an extensive facial planing, but the use of Loo punch or scalpel excision and the suturing of large cysts and scars during the procedure and the filling of valley-like depressions with liquid collagen or silicone after the procedure. These methods of extensive standard procedures and protocols, rigid patient selection, and pre-, during, and postdermabrasion follow-ups are presented so medical staffs can avoid common pitfalls.

Acne Vulgaris↗
PubMed1978

Dermabrasion by diamond fraises revolving at 85,000 revolutions per minute.

Use of a high-speed, air-driven turbo-grinder equipped with diamond fraises that revolve at 85,000 revolutions per minute has improved results in dermabrasions on the face by, it is estimated, 50%. Dermabrasions have been done with this turbo-grinder for scarring from acne, actinic damage, syringomata, lesions of adenoma sebaceum and some other facial conditions. The rapid evaporation, nonimflammability, nonnarcotic, and excellent freezing properties of Freon 12 eliminate the necessity for auxiliary cooling fans. It is thought too that the incidence of secondary infections and keloids have been decreased by use of an ointment of erythromycin (1%) topically during the healing period.

Acne Vulgaris↗
PubMed1976

Non-comedogenic cosmetics.

The need for a "comedogenic-free" cosmetic for acne patients led to this study using the only available mode, the rabbit. To facilitate the formulation of this benign cover-up, a range of cosmetics and ingredients was tested. Many cosmetics, fractions, and modifications of lanolins were comedogenic, as were emulsifiers such as butyl sterate, isopropyl myristate and sodium lauryl sulfate. From this data we incorporated non-comedogenic, into an acceptable cosmetic formulation for patients. The use of this formulation in susceptible acne-prone women reduced the rate of "acne cosmetica" in our clinic patients from 25% to less than 5%. We were unable to confirm a recent study suggesting that sulfur was a potent acnegen.

Acne Vulgaris↗
PubMed1975

Sebum: analysis by infrared spectroscopy. II. The suppression of fatty acids by systemically administered antibiotics.

Various tetracyclines and erythromycins have been used rather empirically for the systemic treatment of acne vulgaris for more than a decade. It has been impossible to accurately evaluate clinically the numerous derivatives and to compare their effectiveness with other antibiotics such as clindamycin. As a substitute for this approach, this present study ranks these antibiotics, when given orally, as to their effectivensss in suppressing the fatty acids in sebum in normal volunteers. As a group, the tetracyclines were more effective than the erythromycins in decreasing the fatty acids, but clindamycin was significantly more potent than either.

Acne Vulgaris↗