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Biomedical subjects

J E Gotcher

Publications and source records attributed to J E Gotcher.

10 recordsLinked to original sources
PubMed1989

Temporomandibular joint noises in infants review of the literature and report of cases.

Temporomandibular joint (TMJ) function and dysfunction in infants and children are poorly understood. Some reports of dysfunction in children and adolescents have appeared in the literature; however, no contemporary reports of TMJ dysfunction in infants have been published. Here we describe three cases of TMJ noises that may represent an anatomic abnormality. Patients' ages at onset were 3 days, 5 months, and 6 months. All noises occurred in the apparent absence of trauma and without other clinical findings. Two cases resolved spontaneously over a 2- to 5-month period. One case is still occurring, but the frequency is decreasing with age. In all cases there was no history of distress on the part of the child during mandibular movements or when the noises occurred. Included is a review of the literature and hypotheses of the etiology of TMJ noises in infants.

Female↗
PubMed1981

Effect of dichloromethane diphosphonate on cortisol-induced bone loss in young adult rabbits.

Cortisol, 2.5 mg/kg, dichloromethane diphosphonate (Cl2MDP), 0.1, 1.0 and 4.0 mg/kg, and combinations of the two were administered daily for 42 days to young adult rabbits (3.9 kg) to determine if Cl2MDP could inhibit development of cortisol-induced osteopenia. A beginning and a terminal control group were included in the experiment. In the terminal controls compared with the beginning controls, the proximal tibia lost cortical and trabecular bone, the distal femur gained cortical bone and the lumbar vertebral body lost trabecular bone. The administration of Cl2MDP alone inhibited bone resorption at those sites where bone loss was occurring. Two cortical bone sites showed gains in bone. The 1.0 mg/kg dose was most effective. In rabbits administered cortisol, bone formation was inhibited; the number of osteoclasts was markedly increased, cortical bone was lost in all the bones examined, and there was no marked effect on trabecular bone. Cl2MDP administered with cortisol partially inhibited cortisol-induced bone loss. The concomitant administration of Cl2MDP did not alter the number of osteoclasts and osteoblasts. The 1.0 mg/kg dose was most effective. The results of this study clearly demonstrated the need to evaluate several bones and different sites within individual bones if erroneous conclusions are to be avoided when studying agents that affect bone metabolism.

Aging↗