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Biomedical subjects

J E Gottesman

Publications and source records attributed to J E Gottesman.

At least 19 recordsLinked to original sources
PubMed1991

Failure of open radioactive 125iodine implantation to control localized prostate cancer: a study of 41 patients.

We studied 41 patients with localized prostate cancer who underwent bilateral pelvic lymphadenectomy with open insertion of radioactive 125iodine. Followup was a minimum of 5 years. Of the patients 13 died: 10 of recurrent prostatic adenocarcinoma (including 4 of 5 with pathological stage D1 cancer) and 3 of unrelated causes within 2 years of implantation without clinical evidence of prostate cancer. Of the 28 remaining patients 16 have known recurrence of cancer (positive bone scan and increasing prostate specific antigen (PSA) level or positive tissue biopsy]. Six patients have strong suspicion of local recurrence with elevated PSA levels (greater than 4.0 in 5) and increasing induration on digital rectal examination. Only 6 of the 41 patients (14.6%) are without evidence of disease. Openly implanted radioactive 125iodine does not appear to control effectively adenocarcinoma of the prostate.

Aged↗
PubMed1985

Infarction-nephrectomy for metastatic renal carcinoma. Southwest oncology group study.

Thirty patients with metastatic renal cell cancer were treated by renal infarction, followed by delayed nephrectomy. All cases were collected over an eighteen-month period, with a minimum follow-up of one year. There were no complete remissions and only one partial remission, which lasted twenty-one months before progression of disease. Three patients had stable disease for at least six months, but eventually all patients showed evidence of progression. After tumor progression was documented patients were treated with intramuscular medroxyprogesterone acetate (Depo-Provera) 800 mg per week. No patient responded to this therapy. Overall, a 28 per cent one-year survival and a seven-month median survival were realized, which is similar to other series in which no therapy or palliative nephrectomy was performed. We conclude that infarction and nephrectomy is not an effective modality in the treatment of metastatic renal cell carcinoma. In addition, medroxyprogesterone was not shown to be significantly active against renal cancer in this study.

Carcinoma, Renal Cell↗
PubMed1981

Recurrence of Wilms tumor--twenty-three years later.

A case of Wilms tumor recurrent twenty-three years after the initial nephrectomy and subsequent radiotherapy is presented. Late recurrence of Wilms tumor is rare, and one must postulate a breakdown in the host's immune surveillance system to explain such an unusual event.

Adult↗
PubMed1978

Isoantigens A, B and H in urinary bladder carcinomas following radiotherapy.

ABH tissue isoantigens were measured by the Specific Red Cell Adherence (SRCA) test in 66 surgical specimens of urinary bladder, including 53 transitional cell carcinomas, 2 squamous cell carcinomas and 11 controls. The SRCA test was strongly positive in 10 of 11 controls. ABH isoantigens were absent or equivocally present in 68 percent of noninvasive carcinomas (stage 0) and in 65 percent of invasive carcinomas. Clinical histories revealed that all patients with invasive carcinoma who had strongly positive SRCA test results had received prior radiotherapy to the bladder region. None of the patients with invasive bladder carcinoma with negative or weakly positive SRCA tests had been radiated. Histopathology of tumors in both groups was similar. Results of this retrospective study support the hypothesis that radiation may induce differentiation in tumors, possibly through an enhancement of Golgi apparatus function. The SRCA test should not be used as a predictor of the biological behavior of future recurrences in patients with bladder carcinoma who have received therapeutic radiation since radiation may produce "false positive" SRCA test results.

ABO Blood-Group System↗
PubMed1978

Anti-refluxing colon conduits for diversion of dilated upper urinary tracts.

Ureteral tailoring and colonic conduit urinary diversion were performed in 10 dogs. 2 wk to 2 mo after ureteral ligation. Two to five months after urinary diversion, radiography and postmortem examination revealed reflux in only 11% of the ureters and no evidence of obstruction at the ureterocolonic anastomosis. Pyelonephritis was observed in a lower percentage of animals so diverted, as compared to control kidneys diverted by means of ileoconduits. These results support the use of anti-refluxing colonic conduits for diversion of dilated upper urinary tracts.

Animals↗
PubMed1978

Gray scale ultrasound of the scrotum.

Clinical differentiation of the various pathological conditions which affect the scrotal contents can be difficult. The value of gray scale ultrasonography was assessed prospectively in 55 patients (110 testes) with specific clinical presentations and was compared to the reported results of other noninvasive imaging procedures. The homogeneous texture of the testes and the coarser pattern of the epididymal region were normally more clearly separable with gray scale signal processing. In this series, a clear differentiation of the origin of an abnormality was possible in 80% of the cases. A negative sonogram was highly reliable. However, the benefits of scrotal ultrasonography can only be evaluated after consideration of the clinical setting and alternative noninvasive diagnostic modalities.

Epididymitis↗
PubMed1977

The Small-Carrion prosthesis for male impotency.

Small-Carrion penile prostheses were implanted in 61 patients who have been followed for 3 to 21 months. Of these 61 patients 55 have achieved satisfactory results, with a return of normal sexual function. The importance of preoperative evaluation and preparation is stressed.

Adult↗
PubMed1977

[Surgical mangement of erectile impotence with special reference to Small-Carrion penil prosthesis (author's transl)].

Due to increasing number of radical surgeries for malignant tumors of the pelvis the incidence of iatrogenically caused erectile impotence rises. Available surgical management comprises implantation of rigid penile prothesis or inflatable device. The authors prefer a rigid implant (Small-Carrion penile prothesis) on account of its simplicity and have been impressed with the results.

Adult↗
PubMed1976

Granulomatous disease of male genitalia.

Five cases of granulomatous disease of the male genitalia are presented. Of these, 3 cases involved foreign-body reactions in which some form of hydrocarbon was the causative agent. In the other 2 cases, idiopathic granulomatous processes were found, and this condition may be secondary to endogenous lipoid degenerative processes.

Adult↗