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Biomedical subjects

J E Lavigne

Publications and source records attributed to J E Lavigne.

9 recordsLinked to original sources
PubMed1976

Beneficial effect of prostaglandin E1 in experimental hemorrhagic shock.

Twelve dogs were subjected to hemorrhagic shock by means of a modified Wiggers technique. Half were treated with prostaglandin E1, 1 microgram per kilogram per minute in 60 milliliters of saline solution, for one hour after shock, while the other half received only an equal amount of saline solution. Those dogs treated with prostaglandin E1 exhibited a significantly increased survival time and cardiac output as well as a significantly lowered total peripheral resistance when compared with those for untreated dogs. The various modes of action by which prostaglandin E1 exerts both its cardiovascular and other long term effects indicate a multisystem effect of the drug.

Animals↗
PubMed1975

Hemodynamics within a canine femoral arteriovenous fistula.

Blood flow and pressures around a canine femoral arteriovenous fistula, constructed from an autogenous carotid artery, were measured to determine the pressure-flow relationships within the fistula, as well as to determine the presence or absence of retrograde flow in the distal artery and vein. The findings indicate that retrograde arterial flow occurs only when the proximal femoral artery is occluded and, even then, the contribution to fistula flow is small and well below control femoral arterial flow. Retrograde distal venous flow is negligible. Pressure within the fistula is high at the arterial end but is rapidly dissipated across the loop fistula to equal systemic venous pressure on the venous side. Modest distal venous hypertension accompanies this type of fistula. For these reasons, a loop-type, arteriovenous fistula is preferable to other types of fistulas for most clinical surgical indications.

Animals↗
PubMed1975

Use of peritoneal lavage in the diagnosis of experimental acute pancreatitis.

Twenty-four dogs were divided into five groups. Under pentothal sodium anesthesia, those in the control group received no further manipulation; another group underwent laparotomy only; and dogs in the last three groups had induced pancreatitis, intestinal ischemia and duodenal perforation, respectively. An analysis was made of serum and peritoneal lavage fluid in the dog of each group at 30 minute intervals for four and one-half hours. Parameters which were significantly elevated in dogs with pancreatitis compared with other groups included fluid amylase, lactate dehydrogenase, proteolytic activity and intestinal alkaline phosphatase and serum amylase. We judge that these biochemical differences in the lavage fluid, when taken with the physical characteristics of the fluid and the clinical symptoms, can significantly aid the clinician in arriving at the diagnosis of acute pancreatitis.

Abdomen↗