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Biomedical subjects

J E Maruchin

Publications and source records attributed to J E Maruchin.

11 recordsLinked to original sources
PubMed1988

Pharmacodynamics of salbutamol in humans.

Twenty patients with mild chronic bronchial asthma (females and males between 45-69 years old) treated with single dose of 0.5 mg at 1 ml of salbutamol were investigated. Measurements of heart rate, blood pressure, peak expiratory flow rate (PEFR) and plasma concentration or glucose, potassium and non-esterified fatty acids-NEFA, and salbutamol plasma levels were recorded at the same time before and 2, 5, 15, 30, 60, 75, 90, 120, 180, 240, and 360 min after salbutamol injection. Decrease in heart rate, blood systolic pressure and metabolic changes correlated with the salbutamol plasma level. Increase in PEFR was elevated much longer.

Aged↗
PubMed1985

Changes in plasma high density lipoproteins (HDL) levels after salbutamol.

Administration of salbutamol--in a single dose of 0.5 mg i.v. and in a dose of 8 mg twice daily during two weeks--was associated with an increase of HDL-cholesterol concentration in the serum of patients with chronic bronchitis and severe airway obstruction. At the end of the second week of oral treatment with salbutamol, the HDL-cholesterol concentration in serum increased by 6.9% (p less than 0.01).

Albuterol↗
PubMed1976

Crystalline free radical of chloropromazine.

The method of preparation and the spectral characteristic of the crystalline free radical of chlorpromazine are described. Two absorption maxima at 770 and 860 nm concomitant with those at 530 and 277 nm were found. The highest rate of dismutation of the radical was 4-4.10(-1) M. sec-1 at pH 7-2. The mechanism of luminescence during the decay of the peroxide form of th radical is discussed.

Chemical Phenomena↗
PubMedDate not supplied

Isolation and fluorometric determination of homovanillic acid in urine and tissues.

The fluorometric method is described for determination of the final product of dopamine metabolism homovanillic acid in urine, amniotic fluid and tissue extracts. The metabolite was isolated using three chromatographic columns (1-Amberlit CG-50, 2-Dowex AG 1 x 2, 8-Aluminium oxide). Oxidation of eluates to emitter was done with potassium ferricyanide in alkalic medium. The use of internal standards made high recovery of compound and a good specificity and sensitivity of detection.

Amniotic Fluid↗
PubMedDate not supplied

Photodimerization of chlorpromazine radical CPZS.+ under the irradiation of UV light.

CPZS.+ radical excited at S atom in the phenothiazine ring was obtained by illumination of aqueous solution of chlorpromazine (CPZ..) for 15 min with UV light (303 nm). The radicals in oxygenated solution formed green, dimeric photoproduct CPZSOOSCPZ (m. wt. 628 +/- 1) lambda max. 741.9 nm, IR spectrum 760, 1470, 3400 cm1, fluorescence emission at 485 nm (max. excitation 365 nm). The dimer decomposed in alkaline methanol (pH 10.0) with intensive luminescence (max. at 500 nm).

Chlorpromazine↗