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Biomedical subjects

J E Mesina

Publications and source records attributed to J E Mesina.

7 recordsLinked to original sources
PubMed2000

Lake Erie College of Osteopathic Medicine's independent study pathway program: an alternative medical school curriculum design.

Lake Erie College of Osteopathic Medicine has developed an independent study pathway as an alternative to the traditional medical school curriculum design. Beginning with the 2001-2002 academic year, three equivalent and distinct curriculum pathways will be available to medical students at the Lake Erie College of Osteopathic Medicine: the lecture/discussion pathway, the problem-based learning pathway, and the independent study pathway (ISP). The ISP program will provide flexibility for students during their preclinical years. Using highly structured faculty-developed modules, students in the ISP program will be responsible for their own learning in a self-directed, independent manner, including when, where, what, and how to study. Examinations will be taken when students consider themselves ready. If examinations reveal deficiencies in student preparation, these deficiencies must be remedied before students continue their studies. Faculty will be available, as needed, to assist the students through difficult concepts and material.

Clinical Competence↗
PubMed1987

The ferret as a model for endogenous synthesis and metabolism of N-nitrosamines.

We have begun to evaluate the ferret as a model for studying gastric nitrosation and nitrosamine metabolism. Jugular cannulation allows convenient dosing and sampling of blood, and this technique has been used to study clearance of N-nitrosodimethylamine (NDMA) after intravenous, intraperitoneal and intragastric administration. NDMA metabolism can be inhibited by 4-methylpyrazole for up to 24 h; the accumulation of endogenously-synthesized NDMA can therefore be observed in animals following pretreatment with this compound. We have studied endogenous NDMA synthesis in animals dosed with dimethylamine and nitrite and in animals to which no NDMA precursors were administered.

Animals↗
PubMed1984

Pulmonary function changes in goats given 3-methylindole orally.

Six adult goats were given 0.2 g of 3-methylindole (3MI)/kg of body weight orally. Lung mechanics and ventilatory function were obtained before 3MI and 2, 4, 6, 24, 48, and 72 hours after 3MI administration. Clinical signs were also monitored. Lungs were removed for gross and microscopic examination and for morphometric analysis from goats that died spontaneously or were killed with an overdose of pentobarbital after 72 hours. The major pulmonary function changes observed included a marked decrease in dynamic lung compliance with a moderate increase in airway resistance, a concomitant hypoxemia, sustained increase in respiratory frequency, a progressive decrease in tidal volume and alveolar ventilation, and increased dead space to tidal volume ratio. A mild metabolic acidosis was also noticed.

Administration, Oral↗
PubMed1983

The effects of unilateral carotid body excision on ventilatory control in goats.

The purpose of this study was to determine whether or not unilateral carotid body excision (UCBE) alters normal respiratory control in awake and otherwise intact goats. We measured resting VE and blood gas tensions and pH and ventilatory responses (VR) to NaCN, dopamine and Doxapram in awake goats before and after UCBE. Resting ventilation, blood gas tensions and pH, and the VR to the above stimuli were not altered by UCBE. During exposure to hypoxia in a hypobaric chamber (PB = 450 torr), PaCO2 decreased in UCBE goats over the first hour, indicating acute hypoxic hyperventilation. During the subsequent 8 h, PaCO2 decreased an additional 5-6 torr, suggesting ventilatory acclimatization to chronic hypoxia (VACH). The response was similar to that observed in intact goats. Acute normoxia following 6 and 8 hr did not completely alleviate the hypocapnia of prolonged hypoxia, further suggesting VACH. We conclude that sufficient redundancy exists in the inputs from the paired carotid body chemoreceptors so that normal ventilatory responsiveness to acute and chronic stimuli is present in goats possessing only a single carotid body.

Acclimatization↗