Biomedical subjects
Publications and source records attributed to J E Mincy.
Two pathologically proved cases of epidermoid tumor of the fourth ventricle are presented; clinical history and computed tomographic, magnetic resonance imaging, and histopathologic findings are included.
Described here are ultrastructural changes in neurons of feline red nucleus exhibiting axon reaction after unilateral rubropsinal tratotomy at the C-2 level and surviving 2 to 65 days. Ultrastructural alterations included neurofilamentous hyperplasia; proliferation of smooth ER; temporary disappearance of organized granular ER with partial substitution by haphazardly arranged, broad cisternal profiles; loss of rosette ribosomes and occurrence of single ribonucleoprotein granules or an intercisternal amorphous density; increased numbers of subsurface cisterns and allied structures, often disposed in stacks; vesiculation and vacuolation of Golgi cisternae; prevalence of autophagic bodies derived in part from Golgi complexes; probable mitochondrial hyperplasia and various qualitative changes in these organelles; an increase in lipofuscin. Dendritic changes paralleled those of perikarya save that proliferation of subsurface cisterns and autophagic bodies was absent. Abnormalities of myelinated axons and boutons occurred and may have originated from retrograde degeneration of cortical neurons induced by lateral funiculotomy. Some perikarya were devoid of axosomatic boutons. Ultrastructural changes varied with the length of postoperative survival and were, at least partly, reversible. Chromatolysis was detectable light microscopically before ultrastructural abnormality appeared. The bearing of transneuronal mechanisms on axon reaction of central neurons and the protective effect of section of axons beyond the site of origin of collaterals are discussed.
Two adolescent brothers were studied because of cramps in the legs following strenuous exercise. The symptoms were maximal at adolescence and later subsided. Serum creatine phosphokinase elevations were significant. Examinations of muscle biopsy material revealed changes compatible with a myopathy. The family consists of seven children. All have eventually developed elevations of serum creatine phosphokinase, which appear to reach the highest point during adolescence. This familial disorder may represent a new myopathy with maximal penetrance at adolescence.
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An encapsulated, intradural, extramedullary ependymoma of the midthoracic spinal cord appeared hyperintense relative to normal spinal cord on long repetition time (TR)/long echo time (TE) images and nearly isointense to cord on short TR/short TE images. Clinical history, myelography, magnetic resonance of the tumor in vivo and of the fresh intact specimen, and histopathology are presented.