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Biomedical subjects

J E Pedersen

Publications and source records attributed to J E Pedersen.

At least 37 records · Page 2Linked to original sources
PubMed1986

Peroperative buprenorphine: do high dosages shorten analgesia postoperatively?

Fifty-two patients undergoing biliary surgery were investigated in a prospective randomized study, in which they received buprenorphine 10, 20, 30, and 40 micrograms X kg-1, respectively, as sole intravenous analgesic as a bolus 15 min before induction of anaesthesia. The anaesthetic was uneventful in all four groups, although when receiving 10 and 20 micrograms X kg-1 almost two-thirds of the patients needed supplemental analgesics during the operation. When receiving buprenorphine in the dosage of 30 and 40 micrograms X kg-1, 50% of the patients requested an analgesic within 5 min of extubation. In contrast, when receiving 10 and 20 micrograms X kg-1 none of the patients requested an analgesic within 1 h of the operation. These findings accord to a certain extent with the presence of a bell-shaped dose-response curve for buprenorphine in humans.

Biliary Tract Surgical Procedures↗
PubMed1985

Postoperative pain relief with naloxone. Severe respiratory depression and pain after high dose buprenorphine.

Buprenorphine 30 and 40 micrograms/kg was given as the sole intravenous analgesic in balanced anaesthesia to 12 patients undergoing cholecystectomy. Significant and severe respiratory depression was found 15 minutes after preoperative loading with buprenorphine. In the immediate postoperative period six patients were in pain. They were treated with naloxone 0.08-0.4 mg leading to a long lasting period of pain relief (median 22 hours).

Adult↗
PubMed1984

Radiation and concurrent chemotherapy for the treatment of Lewis lung tumor and B16 melanoma tumor in C57/BL mice.

C57/BL mice bearing either Lewis lung tumor or B16 melanoma tumor were treated with radiation and concurrent chemotherapy. The treatment results were determined in vivo by tumor regrowth delay assay. When continuous infusion of either Cyclophosphamide (CYCLO) or 5-Fluorouracil (5-FU) or Adriamycin (ADRIA) or Mitomycin-C (MITO-C) was used in combination with continuous radiation at 1 cGy/min, no increase in tumor regrowth delay was observed over that of radiation alone. When multiple drug chemotherapy, FAM (5-FU, ADRIA, MITO-C) was administered in combination with radiation at 80 cGy/min, no increase in tumor regrowth delay was observed over that of radiation alone. In these two murine tumor models, when clinically relevant concentrations of commonly used chemotherapy agents were combined with radiation, no therapeutic advantage was observed.

Animals↗
PubMed1979

Distribution and tumour cytotoxicity of the radiosensitizer misonidazole (Ro-07-0582) in C57 mice.

The distribution and clearance of misonidazole (MIS = Ro-07-0582) were studied in C57 mouse tissues and in transplants of Lewis lung tumour. The half life of the drug in blood after a dose of 1 mg/g i.p. was 3 h. Some tissues, such as liver, were found to have consistently low MIS levels, and this was found to be due to degradation of the drug after removal of the tissues from the host. The in vivo cytotoxicity of MIS to Lewis lung tumour cells was studied using an in-vitro colony assay. After half of the tumours had been irradiated with 10 Gy to kill most of the oxic cells, the mice received i.p. injections of MIS. To simulate the longer drug exposure of human tumour cells (due to the longer half life in man) a repeated injection regime was used in some mice. There was no significant cell kill after a single dose, but with a prolonged exposure to the drug in the multiply injected animals, cell survival was reduced to 50% of control in both the irradiated and unirradiated tumours. Since the hypoxic fraction of the unirradiated tumour is probably not more than 30%, it would appear that MIS is not selectively cytotoxic to hypoxic cells. However, MIS had a much greater cytotoxic effect upon hypoxic Lewis lung tumour cells in vitro, with very little or no effect on cells grown in air. This would support the theory that the presence of hypoxic cells is essential for the expression of MIS cytotoxicity.

Animals↗
PubMed1978

Fresh autotransfusion in major surgery.

The purpose of this study was to investigate whether 600-800 ml of fresh autologous blood, withdrawn just before anesthesia and retransfused at the end of the operation, would reduce early postoperative anemia. Thirty-nine patients undergoing abdominal hysterectomy were autotransfused, while 44, submitted to the same operation, served as controls. Appropriate amounts of lactated Ringer solution were infused during phlebotomy and operation. The cardiovascular system remained stable and diuresis high. Postoperative complications were few and did not prolong hospitalization. The mean peroperative blood loss per patient was 680 ml. Fresh autotransfusion did not improve early postoperative anemia.

Anemia↗
PubMed1977

An attachment for delivery of humidified gas.

A new attachment, to either endotracheal or trachestomy tubes, is described which ensures delivery of gas to the spontaneously breathing patient without significant loss of heat or water vapour. Problems of traction and pressure are minimised when the device is used.

Aerosols↗