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Biomedical subjects

J E Poulsen

Publications and source records attributed to J E Poulsen.

At least 19 recordsLinked to original sources
PubMed1982

Effect of acute selective beta-1-adrenoceptor blockade on hormonal and cardiovascular response to insulin-induced hypoglycaemia in insulin-dependent diabetic patients.

The hormonal and cardiovascular responses to intravenous (i.v.) insulin were studied in 16 insulin-dependent normotensive diabetic patients after acute injection of selective beta-1-adrenoceptor blocking agents. The lowest blood glucose levels were not affected by beta-1-adrenoceptor blockade while the time for reaching nadir was significantly reduced. Plasma adrenaline levels increased significantly during selective beta-1-adrenoceptor blockade. Plasma noradrenaline, glucagon and human growth hormone levels, however, remained unaffected. The insulin-induced tachycardia was not prevented by the beta-1-blockade, and the mean arterial blood pressure was unchanged. The ability to recognize the symptoms of insulin-induced hypoglycaemia persisted in all patients, although less pronounced in nine of them. We suggest that selective beta-1-adrenergic blocking agents may be employed without risk in the treatment of hypertensive insulin-dependent diabetic patients.

Adolescent↗
PubMed1979

The prognosis of insulin dependent diabetes mellitus and the importance of supervision.

1451 patients with IDDM, onset before 1953 and before the age of 30 were followed until death or until 1976. Survival with diabetes, relative survival and the influence of supervision on survival were examined. It is shown that only 50% of the patients survived more than 30 diabetes years. The patients had an overmortality of more than 600% in relation to age and sex matched non-diabetics. Frequent supervisions in the out-patient clinic reduced as well the overmortality as the prevalence of severe complications significantly.

Adolescent↗
PubMed1978

Prognosis of diabetics with diabetes onset before the age of thirty-one. II. Factors influencing the prognosis.

In 307 patients with diabetes mellitus, developed prior to 1933 and before age 31 it was demonstrated that: (1) frequent contact with a specialized diabetes clinic from an early stage of the disease; (2) a good quality of "metabolic control"; (3) a low insulin dose; (4) a body weight of 10% less than ideal; and (5) a mean blood pressure below 100 mm Hg, all had significantly beneficial effects upon the survival. It was also found that patients domiciled in Copenhagen had a significantly better prognosis than patients domiciled outside Copenhagen. Frequent contact with a diabetes centre was accompanied by an appreciable decrease in disabling late diabetic complications.

Age Factors↗
PubMed1976

Morphology of experimental, organ-specific insulitis of the mouse pancreas.

The morphologic and metabolic effect of a single intracutaneous injection of homologous endocrine pancreas in Freund's complete adjuvant (CFA) was studied in 100 mice and compared with control groups which had been (1) immunized with murine insulin in CFA, (2) injected with CFA alone, or had (3) received no treatment. There were no differences between the control groups as regards the morphology of the pancreatic islets, and the glucose tolerance was normal. Mice immunized with islet homogenate exhibited morphological changes in the form of degranulation and cytoplasmic disintegration. These changes involved B-cells as well as A2-cells and were present from 7 to 18 days after the immunization. A significant reduction in glucose tolerance was observed 14 days after the immunization. Another characteristic finding in the islets from the immunized mice was the extra-vascular presence of mononuclear, agranular cells which on the basis of their morphological criteria appeared to represent lymphocytes.

Animals↗
PubMed1975

The impact of August Krogh on the insulin treatment of diabetes and our present status.

The influence of August Krogh on the introduction of insulin preparations in Scandinavia is mentioned, and his outstanding physiological background is outlined. Developments in preparation of insulin depending on the progress in protein-chemistry are summarized. The latest step in the purification of insulin extracted from pork pancreas now allows treatment of diabetics with protamine-pork-insulin without causing formation of insulin-antibodies in at least 90 per cent treated with insulin through several months. In only 3 out of 51 diabetics was it possible to demonstrate insulin-antibodies. This new step may be of great interest in two ways 1) it is now possible to make insulin-estimations in the plasma of insulin-treated cases and 2) it will be possible to find out whether elimination of insulin-antibody-formation will reduce the degree of vascular lesions in diabetics, such lesions being the greatest problem in clinical diabetes.

Diabetes Mellitus↗