Biomedical subjects
Publications and source records attributed to J E Senior.
An account is given of four cases of myasthenia gravis in the dog. All animals showed fatigue, and considerably reduced tolerance to exercise. Recovery followed rest or treatment with neostigmine. Three animals, two of which are still alive, had dilatation of the oesophagus. The fourth eventually died from an aortic body tumour. The occurrence of myasthenia in the dog may be of value in elucidating the cause of the disease in man.
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The inductorium, or induction-coil stimulator, introduced in the late 1830s, provided a means for obtaining repetitive stimuli; thereby allowing the discovery of new properties of excitable tissues. Major physiologic discoveries with the inductorium were tetanic contraction of skeletal muscle, inhibition of the heart, the role of vasomotor nerves, and cortical localization. In the hands of clinicians, it was used to diagnose neuromuscular disease and to produce artificial respiration with body-surface electrodes. Because of the historical importance of this tool, its characteristics are described quantitatively. Although it is no longer used, it has a secure place in the history of biomedical instrumentation.
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Explore the source record for details and available documents.
Explore the source record for details and available documents.
A review of the search for a safe, effective, and inexpensive means of electrical anesthesia.