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Biomedical subjects

J E Sigdell

Publications and source records attributed to J E Sigdell.

At least 19 recordsLinked to original sources
PubMed1995

Studies concerning the optimization of dialysate consumption.

As a continuation of an earlier study, the relation between total mass drainage and total dialysate consumption during a dialysis treatment is studied here. It is again found that a suitable operating condition is to have equal blood and dialysate flows, and that with a reasonable prolongation of treatment time, the same total mass drainage results as for a higher dialysate flow rate, but with a much lower total dialysate consumption.

Hemodialysis Solutions↗
PubMed1986

Clearance of a dialyzer under varying operating conditions.

The clearance of a dialyzer at zero ultrafiltration and zero inlet concentration in the dialysate was studied for varying dialysate flows. It was found that a practically feasible limit can be set to the dialysate flow, above which the gain in clearance is minimal or negligible, resulting more in a waste of dialysate than in increased mass transport. The results suggest a more economical operation of dialyzers, which is of general interest, as well as of special interest in areas where no on-line dialysate preparation is used (e.g., because of unreliable water supplies).

Dialysis↗
PubMed1984

A new operational principle for blood treatment with highly permeable membranes.

Conventional membrane devices for blood treatment have traditionally been operated either as hemofilters or as dialyzers. This article discusses the possibility of combining both aspects in one single device, using a single membrane with a high hydraulic permeability. In fact, the combined function is found to be the only possible mode of operation, using very permeable membranes, but this apparently has so far not been recognized in actual application.

Blood↗
PubMed1982

Calculation of combined diffusive and convective mass transfer.

The clearance of a dialyzer is calculated under the most general conditions, allowing not only for a mixed diffusive and convective mass transfer, but also for a variation along the membrane of the local ultrafiltration, the membrane permeability and the sieving coefficient. The study is then carried on for the case in which these are all constant, to reach a relatively simple expression for the influence of a low ultrafiltration rate on the clearance. In this study, the permeabilities of the boundary layers on both sides are treated as included in the (equivalent) membrane. In an appendix, the stacking of membranes is studied, giving a general law for the calculation of overall permeabilities of a stack of individual membranes, regarded as one (equivalent) membrane (such as a physical membrane with two boundary layers). Permeability data for boundary layers are quoted from earlier works. In other appendices, the variation of the local ultrafiltration along the dialysis path is studied, as well as its effect on the effective permeability of the membrane.

Humans↗