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Biomedical subjects

J E Wahlberg

Publications and source records attributed to J E Wahlberg.

6 recordsLinked to original sources
PubMed1977

Chromium, cobalt and nickel in Swedish cement, detergents, mould and cutting oils.

The concentrations of chromium, cobalt and nickel in 8 brands of Swedish cement, 19 detergents, 28 unused mould oils and 28 unused cutting fluids were determined by atomic absorption spectrophotometry. The total quantity of chromium in cement was 40-115 microgram Cr/g, whereas water-soluble chromium and chromate did not exceed 20 microgram Cr/g. The cobalt concentration was 5-16 microgram Co/g and the nickel concentration 5-59 microgram Ni/g. In detergents the nickel concentration was comparatively higher than that of chromium and cobalt. The highest value observed was 5.7 microgram Ni/g. In mould oils the concentrations were low, never exceeding 1 microgram/g. In cutting fluids the concentrations were low with the exeption of one product which contained 19.4 microgram Ni/g. The clinical implications of the results are discussed and it is pointed out that investigations of used cutting fluids can provide important information concerning possible allergy risks.

Chromium↗
PubMed1977

Assessment of chromium allergy: features of patch test reactions at electron microscopic resolution.

The possible correlation of clinically recorded test reactions and morphological changes at electron microscopic resolution in human subjects allergic to chromate (CrVI) was investigated. The effect of simple occlusion and of vehicles, e.g. distilled water, an alkaline buffer, and petrolatum was also studied 72 hours after application. The results indicate that even simple occlusion causes reactive changes in living epidermal cells. These changes become conspicuous in occlusion with distilled water, more pronounced with petrolatum, and were destructive in the case of the alkaline buffer. Chromate solutions produced varying degress of morphological change but were less pronounced in a vehicle of distilled water, compared with the changes seen when the chromate was combined with the alkaline buffer. Destructive cellular changes were observed in the electron microscope even in sections from test ares where no macroscopical reactions were recorded. When the clinical evaluation of hypersensitivity was done 72 hours after the application of the patch test the morphological changes were too advanced to provide specific pathognomonic information.

Adult↗
PubMed1975

Nickel allergy and atopy in hairdressers.

A study of 35 hairdressers with hand eczema was made during an 18-month period. A total of 29 were test-positive to one or more substances in the standard series and/or to products from their working environment. 40% were allergic to nickel. The prevalence of personal atopy was higher in the nickel-negative than in the nickel-positive. Immunoglobulin E determination was not of assistance in attempts to differentiate between nickel-positive and nickel-negative hairdressers. In 72% the eczema had started before the age of 25 and in 23% after less than 1 year in the profession. The desire is expressed that all hairdressing products shall be labelled in respect to allergen contents, since 46% of the hairdressers reacted to one or more such agents.

Adult↗
PubMed1975

Immunoglobulin E (IgE), an aid in the classification of occupational dermatoses?

During an 18-month period determinations of immunoglobulin E(IgE) in serum were made on all (631) new patients referred to the Department of Occupational Dermatology, Karolinska Sjukhuset, Stockholm. The mean for the entire series was 238 units/ml (U): 280 U for the 323 men and 196 U for the 308 women. The IgE values for the different age groups, clinical diagnoses and sexes are presented. About 20% of the patients with normal IgE (less than 250 U) had a history of atopy. On the other hand about 30% of the patients with pathological IgE value (greater than 1000 U) had no such history. No explanation of this rise of IgE without concurrent atopy was discovered despite detailed laboratory tests. Our impression is that the IgE value has a prognostic significance and that, especially for the question of choice or change of occupation in cases of dermatitis, the determination of IgE is of value.

Adolescent↗