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Biomedical subjects

J E Watson

Publications and source records attributed to J E Watson.

125 records · Page 7Linked to original sources
PubMedDate not supplied

Mapping of a cerebellar degeneration related protein and DXS304 around the fragile site.

We have localized the gene encoding a cerebellar degeneration related (CDR) protein to a region proximal to the fragile site close to DXS98 and DXS105. This gene is polymorphic with the enzyme RsaI and therefore also provides a new genetic marker in this region. We have refined the localization of the locus DXS304 distal to the breakpoint in a patient suffering from Hunter disease. This confirms the localization of DXS304 distal to the fragile site previously suggested by linkage studies and localizes the fragile X mutation to a relatively small region between the Hunter breakpoint and the breakpoint in another hybrid B17.

Base Sequence↗
PubMedDate not supplied

Models for evaluating nursing education programs.

Systematic evaluations of nursing educational programs can be difficult, time-consuming, contentious, and unrewarding processes. Yet there is little doubt of the value of a well-designed, systematic evaluation. Nurse educators and administrators currently face challenges to maximize the value of educational resources by increasing productivity, allocating resources appropriately, and accounting for their use. Credible, ongoing evaluations are necessary for meeting these challenges and maintaining high standards in nursing education. Several heuristic models are available to assist nurse educators and administrators in establishing systematic, ongoing processes of program evaluation. Each of the models described offers a slightly different perspective and organizing framework. Each also has various advantages and disadvantages, depending on individual program needs.

Education, Nursing↗
PubMedDate not supplied

Nutritional intervention in hyperlipidemia.

Sufficient evidence from laboratory, epidemiological, and clinical studies indicates that blood cholesterol level is an important risk factor for coronary heart disease and that lowering elevated blood cholesterol levels can reduce that risk. Hyperlipidemia can be successfully treated in most people by use of individualized, progressive, nutritional intervention strategies. Nurses must be appropriately educated in dietary assessment techniques, nutritional education, and patient counseling in order to implement these strategies effectively. Recent advances in nutritional intervention focus on a series of progressive phases for dietary reduction of fat that interact with variables associated with the individual's characteristics and life-style. Nurses in all settings see patients who require intervention to lower elevated blood cholesterol. Important contributions to therapy can be made by nurses in the areas of screening, patient education, promotion of behavioral change, monitoring dietary change and patient outcomes, and integration of nutritional intervention with other therapies. The nutritional intervention aspect of health promotion is integral to nursing practice.

Dietary Fats↗
PubMedDate not supplied

Implementing continued clinical competency evaluation in the emergency department.

Nurse educators are challenged with the task of assuring that those who practice emergency nursing do so with competence. Yet beyond entry level competency verification, few nurse educators have implemented programs documenting continued clinical competence. In this article, the authors describe a cost-effective, practical approach to designing a competency verification program.

Clinical Competence↗
PubMedDate not supplied

Nursing faculty concerns regarding the adoption of computer technology.

This article describes a study conducted to determine nursing faculty concerns about the use of computer technology. Study participants answered a standardized questionnaire (Stages of Concern) designed to measure concern about innovation adoption, and an author-developed survey, which included questions on level of technology use. The questionnaire and survey were given to nursing faculty before and after their participation in a series of computer technology and literacy workshops. Initially, most workshop participants were low-level computer users whose concerns about technology decreased after the workshops. Some workshop participants also experienced a statistically significant increase in their comfort levels in the use of computer applications. Results support the Stages of Concern questionnaire as a tool to monitor the technology integration process and to guide ongoing faculty development efforts.

Attitude to Computers↗
PubMedDate not supplied

Altered protein binding of quinidine in patients with atrial fibrillation and flutter.

STUDY OBJECTIVES: To determine if alpha1-acid glycoprotein (AAG) concentrations are altered in patients with atrial fibrillation and flutter (AFF), and to establish if fluctuations in AAG change the free fraction of quinidine. DESIGN: Prospective, controlled, nonrandomized. SETTING: Tertiary care medical center and outpatient clinics. PATIENTS: Thirty patients with AFF and 16 matched controls. INTERVENTIONS: Serial blood samples were collected from patients with AFF at baseline and for 28 days after cardioversion. The control group received no treatment and a single blood sample was obtained. MEASUREMENTS AND MAIN RESULTS: Concentrations of AAG were measured by Laurell-Rocket immunoelectrophoresis. Quinidine concentrations were determined by fluorescence polarization immunoassay using the Abbott TDx system. Baseline AAG concentrations in patients with AFF (122 +/- 55 mg/dl) were significantly increased compared with the control group (62 +/- 28 mg/dl, p<0.0005). Concentrations of AAG remained elevated after conversion to sinus rhythm and did not significantly change over the study period, regardless of method of cardioversion (p>0.2). In patients with AFF, the free fraction of quinidine at the highest AAG concentration was 8.5 +/- 2.3%. This was significantly reduced compared with the value in the control group (12.5 +/- 3.0%, p<0.05) as well as that in patients with AFF at the lowest AAG concentration (11.0 +/- 2.5%, p<0.05). Overall at the highest AAG concentration, patients with AFF had a relative reduction in the quinidine free fraction by 32% compared with controls. Regression analysis showed an indirect relationship between serum AAG concentration and the unbound fraction of quinidine (r=0.56) CONCLUSIONS: Concentrations of AAG are increased in patients with AFF and remain elevated for at least 28 days after cardioversion. Elevated AAG concentrations significantly reduce the free fraction of quinidine.

Adult↗
PubMedDate not supplied

Implementing instructional technology. Strategies for success.

This article describes strategies for the integration of computer technology in a university-based school of nursing. Faculty concerns related to use of computer technology were assessed in a previous study. A series of computer technology and literacy workshops were developed based on this assessment. Computer use increased and faculty concerns about technology decreased after workshop participation. Other strategies to integrate computer technology include developing an informatics committee and planning and initiating a technology infrastructure consisting of hardware and software resources, and a local area network. Strategic planning was initiated placing increasing emphasis on curriculum integration of computer technology and nursing informatics.

Attitude to Computers↗