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Biomedical subjects

J E van Dijk

Publications and source records attributed to J E van Dijk.

At least 73 records · Page 4Linked to original sources
PubMed1986

Lobular capillary haemangiomas in young horses.

Seven cases of cutaneous haemangiomas in young horses are described, characterized by scattered, well demarcated but unencapsulated lobules, consisting of capillary sized vascular structures, separated by strands of fibrous tissue. In one case, a more cellular variant was distinguished with minor vasoformative capacity. The morphological features of these haemangiomas are compatible with bovine cutaneous angiomatosis and human granuloma pyogenicum. The lesions are considered to be vascular tumours rather than hamartomas or granulation tissue and "lobular capillary haemangioma" is suggested to designate this type of haemangioma. In one tumour, cavernous vascular structures were also present in addition to the capillary structures and so this tumour is considered to be a combined capillary and cavernous haemangioma.

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PubMed1985

[Autochthonous babesiosis in dogs in the Netherlands?].

For the first time cases of babesiosis have been diagnosed in dogs that had not been abroad. Three cases were seen in the province of Gelderland (Bennekom, Elspeet), two in North-Holland (Koog aan de Zaan). A female Dermacentor reticulatus tick, the main vector of the disease in Europe, was found on one of the dogs at Koog; previously specimens of this tick species had only occasionally been seen on dogs returning from abroad. Serological evidence was obtained that in at least four of the cases European Babesia canis, transmitted by Dermacentor ticks, was involved.

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PubMed1985

Biological and pathological aspects of the mammalian small intestinal permeability to macromolecules.

The literature on the biology and pathology of mammalian small intestinal permeability to macromolecules is reviewed. In mammals, macromolecules may penetrate the epithelial layer of the small intestinal mucosa, especially in the neonatal period. The neonatal uptake and transport of immunoglobulins is important in the acquisition of passive immunity in the newborn. In the mature small intestine the uptake of macromolecules almost ceases, except in M-cells. Excessive uptake and transport of macromolecules has been demonstrated in several experimental and spontaneous gastrointestinal diseases, in which increased concentration of macromolecules in the small intestinal lumen and/or damage of one or more components of the small intestinal mucosal barrier is present. Finally, methods to study macromolecular permeation of the small intestine are discussed.

Animals↗
PubMed1985

Biology and pathology of the intestinal M-cell. A review.

The literature of the intestinal M-cell, which is part of the epithelium covering the gut-associated lymphoid tissue (GALT), is reviewed. Attention is paid to the localization, structure, origin and function of this cell, under both normal and pathological conditions.

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PubMed1985

Freeze fracture morphology of thyroid tight junctions in goats with different thyrotropin stimulation.

In the thyroid follicles and blood of goats with congenital hypothyroidism and goiter, abnormal iodoproteins (e.g. iodoalbumin) are found. To study the mechanism involved in the passage of these proteins between the follicles and the blood, the morphology of tight junctions in goiters and normal thyroids of goats was studied by means of freeze fracturing. The T4 and TSH levels of 16 goats were measured by RIA. Based on the TSH levels, the goats could be divided into three groups: a euthyroid group of eight goats with TSH levels between 28 and 55 mU/liter, a hypothyroid group of six goats with TSH levels higher than 199 mU/liter, and an intermediary group of two goats with TSH levels of 120 and 124 mU/liter, respectively. The euthyroid and intermediate animals had normal T4 levels (less than 49 nmol/liter), except for three newborn goats, which had T4 levels above 250 nmol/liter. The hypothyroid goats had T4 levels below 43 nmol/liter. The mean numbers of strands composing the tight junctions were negatively correlated with TSH levels. Hence, the tight junctions of the glands of hypothyroid goats are narrower and are composed of fewer strands than those of normal thyroids. This reduction in tight junction complexity may provide an explanation for the leakage of proteins into the follicles of goitrous glands.

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PubMed1985

Prenatal diagnosis of a thyroglobulin synthesis defect in goats.

A strain of goats with congenital goitre due to a thyroglobulin (Tg) synthesis defect was studied. All goats excreted low molecular weight iodinated material (LOMWIOM) in their urine, but non-goitrous goats excreted in the LOMWIOM fraction less than 5 micrograms iodine per 24 h and the goitrous ones more than 15 micrograms iodine per 24 h. Prenatal diagnosis of the Tg synthesis defect in goats is possible since non-goitrous goats pregnant with goitrous kids excrete in the LOMWIOM fraction more than 10 micrograms iodine per 24 h while non-goitrous goats pregnant with non-goitrous kids excrete 10 micrograms or less iodine per 24 h as LOMWIOM. In 24 out of 25 cases a correct diagnosis could be made in the last 47 days of pregnancy. We argue that prenatal diagnosis of analogous defects in man may also be possible, using the excretion of LOMWIOM in maternal urine as yard-stick. By means of field desorption mass spectrometry (FOMS) and high performance liquid chromatography (HPLC) monoiodohistidine was identified as the major component of the LOMWIOM fraction in the urine of goitrous goats.

Animals↗
PubMed1984

The effect of oral immunization on the population of lymphocytes migrating to the mammary gland of the sow.

Sows were immunized orally with live Escherichia coli according to various immunization schedules. Six pregnant gilts were used; 4 immunized at various intervals during the last month of gestation, 1 control immunized after parturition following suppression of lactation by weaning and 1 non-immunized control. The effect of oral vaccination on cell populations from lymphoid organs was studied. The in vitro proliferative responses of the cell populations to K88 antigen, anti-Ig sera and mitogens were used to demonstrate the distribution of sensitized lymphocytes over different lymphoid organs. The capacity of these cells to produce antigen-specific Ig was determined by in ovo translation of their mRNA. Oral administration of antigen resulted in the appearance of K88-positive cells in lymphoid organs. In lactating sows, sensitized cells preferentially occurred in the mammary lymph nodes, whereas after suppression of lactation such a distribution was not seen. A possible route of migration of sensitized lymphocytes is discussed in relation to the local immune response. The antibody isotype produced by sensitized lymphocytes seemed to depend on the immunization schedule. The most effective schedule was one starting early in gestation and comprising frequent administration of antigen. This caused an optimal distribution of sensitized lymphocytes capable of IgA production.

Animals↗
PubMed1983

[Systemic complications of tumors].

Tumours may give rise to systemic complications, among others by the release of specific substances. The accompanying symptoms are referred to as paraneoplastic syndromes. These complications have a marked effect on the course run by the disease. A number of common syndromes which are easy to diagnose, are discussed in a survey of the literature, namely: cachexia, anorexia, fever, hypercalcaemia, hypoglycaemia, anaemia and coagulation defects. Attention is paid to the occurrence of the syndromes in man and dogs, the relationship with specific forms of tumour, the pathogenesis and some forms of possible therapy.

Anemia↗
PubMed1981

[Clinical and pathological features of Haemophilus pleuropneumoniae infection in pigs (author's transl)].

The incidence of Haemophilus pleuropneumoniae (= H. parahaemolyticus or HPP) infection in fattening pigs showed a marked increase in the Netherlands during the past five years. The clinical picture on pig-breeding farms has been known for an even longer period. A peracute, acute and subacute chronic form, i.e. stages marked by exudation, proliferation and desquamation, and sequestration respectively can be differentiated. Clinical features of the (sub)acute stage of HPP infection consist in severe dyspnoea, high temperature and bloody foam from the nose and/or at the mouth. When the infection runs a chronic course, the clinical symptoms are less specific. The bacteriological diagnosis, treatment and prevention are discussed, attention also being paid to the possibility of vaccination.

Animals↗
PubMed1980

[Morphological characteristics of haemorrhagic enteritis in dogs caused by parvo-like viruses (author's transl)].

Various outbreaks of parvo-like virus infection in dogs are reported. A form of haemorrhagic enteritis was observed, which was microscopically characterized by a hypo-regenerative villous atrophy of the small intestine, which bears a close resemblance to the typical lesion of feline panleucopenia. This pathomorphological feature may be regarded as typical of canine enteritis due to a parvo-like virus.

Animals↗
PubMed1979

[Fractures of the vertebrae in newborn calves (author's transl)].

A letter to the Editor on fractures of the vertebrae in newborn calves is commented upon (Tijdschr. Diergeneesk., 104, 557, (1979)). Supplementary data is supplied and a theory regarding the pathogenesis is suggested. Intense muscular contractions during an attack of asphyxia could be the cause of these fractures of the vertebrae. Although non-genetic factors are bound to play an important role in the pathogenesis of asphyxia, genetic factors (probably showing a hereditary pattern which is more complex than singly recessive) also may help to produce these fractures.

Animals↗
PubMed1978

Hereditary congenital goiter with thyroglobulin deficiency in a breed of goats.

Hereditary congenital goiter occurring in an inbred breed of goats is reported. The goitrous goats were severely hypothyroid. Thyroglobulin-related antigens could only be detected by radioimmunoassay in amounts of 0.03% of the total protein concentration in the 105,000 x g supernate of the goitrous gland, which corresponded with 8 microgram soluble thyroglobulin-related antigens/g tissue. After treatment with digitonin, 4 microgram thyroglobulin-related antigens/g tissue could be extracted from the sediment. This means that the gland contained about 12 microgram thyroglobulin-related antigens/g tissue (normal about 100 mg/g). However, no thyroglobulin (19S) could be detected by ultracentrifugation experiments, immunodiffusion, or immunoelectrophoresis. Iodinated proteins with sedimentation constants of 3-9S were found. Among these iodinated macromolecular compounds, iodinated "albumin" and some non-hydrolysable iodinated material was found. These last mentioned components were also found in the blood, indicating a leakage from the gland. As described for comparable cases, these results indicate a defect in thyroglobulin synthesis or its regulation.

Animals↗
PubMed1978

Euthyroidism via iodide supplementation in hereditary congenital goiter with thyroglobulin deficiency.

We have studied hereditary congenital goiter in an inbred strain of goats. On a normal diet, the goats were hypothyroid and iodide taken up by the gland was released rapidly in the form of iodinated macromolecular material. This resulted in a low thyroidal iodine pool. An extremely low amount of thyroglobulin-related antigens (12 microgram/g tissue; normal, 100 mg/g tissue) was detected in the goitrous gland by RIA. Addition of 1 mg I-/day to the diet made the goats euthyroid and the serum protein-bound iodine increased to high values. Even under these conditions, however, the amount of thyroglobulin-related antigens was not significantly elevated (19 microgram/g tissue). On sucrose gradient, these antigens sedimented in the 7S region. No thyroglobulin-related antigens sedimented at 12S or 19S. Besides iodoalbumin, a heterogeneous group of abnormal iodoproteins containing T3 and T4 was observed with this high iodide intake and may have accounted for the hormone production. The abnormal iodoproteins had a molecular weight of 300,000-500,000 and a sedimentation value of about 7S. From these findings, we conclude that these goats were unable to synthesize thyroglobulin but with excess iodide, there was sufficient formation of T3 and T4 in the abnormal iodoproteins to make the animals euthyroid.

Animals↗
PubMed1978

Erythrocytic forms of Theileria velifera.

The enigmatic veil associated with the cattle parasite Haematoxenus veliferus has been shown to be crystallike in ultrastructure and to stain with benzidine like haemoglobin. The ultrastructure of the organism is similar to that of other theilerial parasites. As less distinct veil-like structures are known to occur with some other Theileria species, and in one case, have also been shown to be crystalline in structure, it is proposed to sink the genus Haematoxenus as a synonym of Theileria.

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