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J Eells

Publications and source records attributed to J Eells.

5 recordsLinked to original sources
PubMed1996

Fetal raphe transplants reduce seizure severity in serotonin-depleted GEPRs.

This study investigated whether transplantation of fetal raphe tissue into genetically epilepsy-prone rats (GEPR-3s) would reduce the severity of seizures previously exacerbated by depletion of brain serotonin. Mild-seizure GEPR-3s were depleted of brain serotonin by 5,7-dihydroxytryptamine (DHT) and evaluated for seizure severity. Rats then received 15-day fetal raphe tissue, fetal neocortical tissue or were sham grafted. GEPR-3s treated with 5,7-DHT showed increased seizure severity following depletion of serotonin and subsequent reductions in severity as a result of fetal raphe transplantation. Sham- or neocortex-grafted rats maintained elevated seizure severity scores throughout the study. Prominent raphe or cortical grafts were observed within the third ventricle of GEPRs at autopsy. These findings show that transplantation of fetal raphe tissue promotes lasting reductions in increased seizure severity resulting from depletion of serotonin in the GEPR brain.

5,7-Dihydroxytryptamine↗
PubMed1984

Deoxynucleoside and vitamin transport into the central nervous system.

Several essential substances for the mammalian brain including certain vitamins and deoxynucleosides do not enter the brain in appreciable amounts directly through the cerebral capillaries, the blood-brain barrier; rather these substances are transported from blood into cerebrospinal fluid (CSF) by specific, carrier-mediated transport systems in the choroid plexus, the anatomic locus of the blood-CSF barrier. From the CSF, these substances then enter the brain. The evidence supporting the notion that the choroid plexus is important in the transfer of ascorbic acid, folates, and pyrimidine deoxynucleosides from blood into CSF is summarized. This evidence provides strong support for the theory that the CSF is, in fact, a nourishing liquor, although an incomplete one, for developing and adult mammalian brain.

Animals↗