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Biomedical subjects

J Elis

Publications and source records attributed to J Elis.

At least 55 records · Page 3Linked to original sources
PubMed1979

Ontogenic drug studies in calves. I. Age dependent salicylate levels and metabolism.

Acetylsalicylic acid (ASA) was administered to 52 Friesian calves 1--60 days old by oral route in the field, 63.5 mg/kg body weight constantly between 9 and 10 a.m., i.e., 3--4 h after morning feeding. The animals were divided according to age into groups. Total salicylate levels, salicylic acid and salicyluric acid plasma levels were determined up to 6 h after administration. The older the animals, the lower were the total salicylate and salicylic acid levels and the higher the salicyluric acid levels. The age dependence is highly significant during the first two weeks of life. Glucuronides could not be detected in quantitatively measurable amounts.

Aging↗
PubMed1978

The distribution of sodium salicylate in the human fetus.

The distribution of sodium salicylate was investigated in the fetuses of 18 mothers in the fifth or sixth month of pregnancy which had to be interrupted for medical reasons. Ninety-six min after drug administration, the salicylic acid levels in mother and fetus blood are almost equal. The highest drug levels in fetus tissue were found in the kidney, the lowest in the brain. In amniotic fluid, only traces of salicylic acid were estimated. A limited number of suitable cases made the exact statistical evaluation impossible.

Adult↗
PubMed1978

Some cytostatic and pharmacological properties of 2,3-dihydro-1,3-6H-oxazine-2,6-dione ("3-oxauracil").

Cytostatic effects and some pharmacological properties of a new metabolic inhibitor "3-oxauracil" were studied. The cancerostatic effect was examined on 7 experimental tumors in mice and on two types of tumors in rats. After the i. p. application of 20 mg/kg, there was both a statistically significant decrease of tumor weight and increase of animals' survival time in NK lymphoma of mice. Significant changes in one of both parameters followed occured in all experimental tumors after the i. p. application but only in the Krebs ascitic carcinoma after the oral application of "3-oxauracil". The acute toxicity of the substance in water was 322 mg/kg i. p. and 850 mg/kg p. o. The ethanol solutions were more toxic. The distribution of the 3H- and 14C-labeled substance was followed up in blood, urine, liver, brain and kidney. After the p. o. application, the radioactivity peak was reached after 2 hr in blood and high radioactivity levels were found in kidney followed by brain and liver. 96 hr after the drug was applicated perorally, only 60% of radioactivity was found in urine.

Administration, Oral↗