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Biomedical subjects

J F ADAMS

Publications and source records attributed to J F ADAMS.

At least 19 recordsLinked to original sources
PubMed1964

THE URINARY EXCRETION AND TISSUE RETENTION OF CYANOCOBALAMIN BY SUBJECTS GIVEN REPEATED PARENTERAL DOSES.

The urinary excretion of injected cyanocobalamin was studied in 30 previously untreated vitamin B(12)-deficient patients by measuring the urinary radioactivity after repeated injections of (58)Co vitamin B(12). The dose range used was 54 to 30,000 mug., each patient receiving the same dose at each injection. The results show that there is no constant trend to the excretion of greater or smaller proportions of the amount injected. It is also shown that there is a wide variation in the amounts excreted by each individual and between individual patients and that the capacity of the tissues to retain injected cyanocobalamin is very great, the amounts retained often being greatly in excess of the normal body stores. The excretion of radioactivity after parenteral infections of (58)Co vitamin B(12) was usually complete within 24 hours but exceptions to this were seen. The significance and value of the results is discussed.

Anemia↗
PubMed1963

The reliability and reproducibility of the Schilling test in primary malabsorptive disease and after partial gastrectomy.

A study of the reproducibility and reliability of the Schilling test in patients with primary malabsorptive disease and after partial gastrectomy is reported. The value of the test was assessed by repeated tests in each patient. Consistently normal or abnormal results were obtained in only one of the seven patients with primary malabsorptive disease and in only two of the eight patients who had undergone partial gastrectomy. From these results it is concluded that the result of a single test may be of little clinical value. Assessment of the results suggests that the mean value for a series of Schilling tests may give some indication of value clinically about the capacity to absorb radioactive vitamin B(12) at the time of the tests at least in patients who have undergone partial gastrectomy. The significance of the findings is discussed, particularly in relation to the aetiology of post-gastrectomy megaloblastic anaemia.

Anemia, Macrocytic↗
PubMed1961

The urinary excretion of assayable vitamin B12 and radioactivity after parenteral 58Co B12 in man.

Evidence is presented that after injection of radioactive vitamin B(12) in man, there is a close correlation between the amount of radioactivity excreted and the amount of assayable vitamin B(12) excreted, and thus that the amount of radioactivity excreted is a true measure of the vitamin B(12) excreted. The possible reasons for this occurrence are discussed and it is suggested that in the body vitamin B(12) does not exist as such but as an analogue or active derivative.

Cobalt↗