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Biomedical subjects

J F Bigger

Publications and source records attributed to J F Bigger.

At least 19 recordsLinked to original sources
PubMed1975

In vitro corticosteroid: correlation response with primary open-angle glaucoma and ocular corticosteroid sensitivity.

The transformation of human peripheral blood lymphocytes can be inhibited by corticosteroid compounds. In an in vitro study of 100 patients with primary open-angle glaucoma and various degrees of ocular pressure responsiveness to corticosteroid testing, varying degrees of sensitivity to corticosteroid compounds existed systemically in the circulating lymphocyte. A high correlation exists between the level of corticosteroid sensitivity in the lymphocyte and in the eye. In vitro cellular systems may be useful in evaluating the molecular basis of the variability in corticosteroid response, and in understanding the pathogenesis of corticosteroid-induced ocular hypertension and primary open-angle glaucoma.

Depression, Chemical↗
PubMed1975

Comparison of in vitro corticosteroid response in pigmentary glaucoma and primary open-angle glaucoma.

We used an in vitro assay utilizing corticosteroids to inhibit transformation of peripheral blood lymphocytes to evaluate a group of 20 patients with pigmentary glaucoma. The pigmentary glaucoma patient group did not manifest the markedly increased cellular sensitivity to corticosteroids associated with primary open-angle glaucoma. If increased sensitivity to corticosteroids plays an essential role in the pathogenesis of primary open-angle glaucoma, then pigmentary glaucoma appears to be etiologically, as well as clinically, a separate entity.

Adult↗
PubMed1975

Glaucoma with elevated episcleral venous pressure.

A chronic elevation of the episcleral venous pressure may occur after venous obstructive disease or arteriovenous fistulas in the orbit, head, neck, or mediastinum. Idiopathic and familial occurrences of elevated episcleral venous pressure have been reported. Association with an increased episcleral venous pressure is a rise in intraocular pressure which, if of sufficient magnitude and duration, may cause cupping of the optic nerve and visual field loss. A case of glaucoma with visual field loss secondary to elevated episcleral venous pressure is presented. Recognition of the etiology of such cases is important, since the management of these patients differs from that of patients having primary open-angle glaucoma.

Female↗