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Biomedical subjects

J F Dammann

Publications and source records attributed to J F Dammann.

At least 19 recordsLinked to original sources
PubMed1997

Reflections on the evolution of cardiopulmonary bypass.

The concept of cardiopulmonary bypass is more than a century old. Although the first clinical application occurred in 1953, there were great deficits in knowledge and materials that had to be overcome before we could achieve the outcomes of cardiac surgery that we have today.

Cardiac Surgical Procedures↗
PubMed1985

Left ventricular hyperkinesia at rest and during exercise in normotensive patients 2 to 27 years after coarctation repair.

The short- and long-term results of effective surgical repair of coarctation of the aorta on left ventricular mass and function in 48 patients were evaluated using echocardiography and stress-gated radionuclide angiography. Thirty-two of the 48 patients who had no additional cardiac problems and had technically adequate radionuclide angiograms form the basis for this report. Among these, three had mild systolic hypertension and none had significant aortic valve dysfunction. Age at the time of study ranged from 6.5 to 59 years (mean 27). Age at the time of surgery ranged from 3 months to 34 years (mean 12 years). Duration from surgery to the time of noninvasive study ranged from 2 to 29 years (mean 15). In the 32 patients, left ventricular mass was 120 +/- 20 g/m2, compared with a control value of 87 +/- 10 g/m2. Mean left ventricular ejection fraction was elevated to 69.2 +/- 1.6% at rest (control 60 +/- 1.3%) and 78.8 +/- 1.3% during exercise (control 70 +/- 1.7%) (p less than 0.01). The systolic ejection rate was significantly increased (p less than 0.01) and end-systolic volume significantly decreased (p less than 0.01) compared with values in control patients. There was no correlation between ejection fraction and either age at the time of surgery or years since surgery. These findings of hyperdynamic left ventricular function and increased left ventricular mass without apparent cause many years after coarctation repair raise important questions as to mechanisms, extension to other forms of afterload stress that have been surgically or medically relieved and long-term outcome.

Adolescent↗
PubMed1979

PEEP: its use in young patients with apparently normal lungs.

PEEP has been advocated for use in patients with the acute respiratory distress syndrome characterized by a marked reduction in FRC. It has not been advocated for patients with apparently normal lungs requiring prolonged mechanical ventilation. We have done inert gas washouts on five young patients comparing no PEEP to 10 cm H2O PEEP. Four of the five showed a significant improvement in PaO2, a decrease in AaDO2 and Qs/Qt, the fifth a slight improvement on PEEP. Arterial washouts were significantly faster on PEEP in all patients suggesting a decrease in intrapulmonary shunting. Airway washouts in the initial phase were faster off PEEP suggesting an increase in lung volume and FRC with PEEP. Later portions of the curve were faster on PEEP suggesting improved distribution of ventilation. These findings suggest that PEEP might be of significant value in treatment of patients requiring prolonged mechanical ventilation for reasons other than lung abnormalities.

Adolescent↗