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Biomedical subjects

J F Dicello

Publications and source records attributed to J F Dicello.

28 records · Page 2Linked to original sources
PubMed1976

Initial comparative response to peak pions and x-rays of normal skin and underlying tissue surrounding superficial metastatic nodules.

Given the limitations of available material and methods for measuring skin response, the relative biological effectivenss (RBE) for the development and healing of skin reaction to pions in this experiment is 1.43. This is based on data obtained from a patient with malignant melanoma, in whom multiple skin nodules and the surrounding normal skin were randomized into three dose levels for pions and x-rays. The RBE for skin reaction was obtained while the skin tumor nodules appeared to regress at least as rapidly with pion therapy as with x-rays. Without benefit of adequate observation of time required for nodule regrowth, any estimate of tumor RBE is speculative.

Dose-Response Relationship, Radiation↗
PubMed1975

Microdosimetry of negative poins at LAMPF.

Lineal energy distributions and linear energy transfer (LET) spectra are being measured at the biomedical facility of the Los Alamos Scientific Laboratory for a negative pion beam having an initial momentum of 168 MeV/c. The results show that the fraction of the dose for lineal energies greater than 50 keV/mum is approximately 2% in the plateau and approximately 12% at the Bragg peak. Preliminary data indicate that the high lineal energy (and high LET) component increases significantly in the region slightly downstream from the peak.

Elementary Particles↗
PubMed1975

Biological effects of the Los Alamos meson beam on cells in culture.

Preliminary measurements of the biological effects of negative pions on cells in culture are reported. Cell survival as a function of depth was obtained by using gelatin to suspend the cells. The results indicate that the effects are more pronounced at the peak portion of negative pions. Cell-survival curves were also obtained under oxygenated and hypoxic conditions. The biological effectiveness at the peak was found to be a factor of 2.0 higher than at the plateau. The oxygen enhancement ratio was 1.5 at the peak. No significant differences in biological effects were observed above 14 mm in the peak region.

Animals↗