Lofepramine is a tricyclic antidepressant related to imipramine. Meta-analyses were carried out with respect to efficacy and tolerability by combining outcome and adverse reaction from over 20 controlled trials comparing lofepramine with other tricyclic antidepressants. Lofepramine was at least as effective as the comparators with fewer adverse effects. In particular, the risk/benefit ratio seemed superior to the comparators amitriptyline, imipramine, clomipramine, maprotiline and desipramine.

Clinical Trials as Topic↗

PubMedDate not supplied

[Detection of anxiolytic effects of suriclone on stress induced by dental surgery].

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Adult↗

PubMedDate not supplied

[A double-blind comparison between mianserin and imipramine (author's transl)].

Fifty-four depressed patients aged 18 to 65 years were treated for 4 weeks with a daily dose of either 60 mg mianserin or 150 mg imipramine in a double-blind controlled trial. The results which were measured on the Hamilton rating scale, on the Beck and on the Overall rating scale, on the brief psychiatric rating scale (BPRS) and on a global rating scale, did not show any significant difference relative to the antidepressive efficiency of both products. The frequency of side-effects however was significantly lower in the mianserin group than in the imipramine group.

Adolescent↗

PubMedDate not supplied

[Meningioma of the optic nerve sheath arising near the globe--symptomatic and therapeutic discussion].

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Adult↗