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Biomedical subjects

J F Drummond

Publications and source records attributed to J F Drummond.

At least 19 recordsLinked to original sources
PubMed1999

Intraosseous fibrous lesions of the jaws: a manifestation of tuberous sclerosis.

Four patients previously diagnosed with tuberous sclerosis are reported with intraosseous fibrous lesions of the jaws. Review of the literature revealed comparable pathosis occurring in extragnathic bones and several previous reports of similar lesions within the jaws. Therefore, these intraosseous fibrous proliferations are thought to represent an intraoral manifestation of tuberous sclerosis and not coincidental findings. In all 4 cases, the tumors demonstrated significant collagenization with numerous interspersed plump fibroblasts. Although histopathologically similar, the features of the lesions are not specific and also can be found in desmoplastic fibromas and simple odontogenic fibromas. The definitive diagnosis requires appropriate clinicopathologic correlation.

Adolescent↗
PubMed1999

Leukoplakia of the maxillary vestibule--an association with Viadent?

OBJECTIVE: This report investigates a possible correlation between chronic use of Viadent products and the subsequent development of leukoplakia in the maxillary vestibule. STUDY DESIGN: A retrospective review of 88 patients with leukoplakia of the maxillary vestibule is presented. Prevalence of Viadent use was determined in this group and in a group of 100 randomly selected adults who presented themselves for routine preadmission screening at a dental school. RESULTS: Of the patients diagnosed with leukoplakia of the maxillary vestibule, 84.1% reported having used Viadent, whereas the prevalence of use was only 3% in the 100 randomly selected adults. CONCLUSIONS: Use of Viadent products appears to be associated with an increased prevalence of leukoplakia in the maxillary vestibule.

Adult↗
PubMed1995

A light and scanning electron microscopic evaluation of electro-discharge-compacted porous titanium implants in rabbit tibia.

This study used light and scanning electron microscopic (SEM) histomorphometric methods to quantitate the rate of osseointegration of totally porous titanium alloy (Ti-6Al-4V) implants prepared by a novel fabrication technique--electrodischarge compaction (EDC). EDC was used to fuse 150-250-micrometer spherical titanium alloy beads into 4 X 6 mm cylindrical implants through application of a 300-microsecond pulse of high-voltage/high-current density. Two sterilized implants were surgically placed into each tibia of 20 New Zealand white rabbits and left in situ for periods corresponding to 2, 4, 8, 12, and 24 weeks. At each time point, 4 rabbits were humanely killed, and the implants with surrounding bone were removed, fixed, and sectioned for light and SEM studies. The degree of osseointegration was quantitated by means of a True Grid Digitizing Pad and Jandel Scan Version 3.9 software on an IBM PS/2 computer. The total pore area occupied by bone was divided by the total pore area available for bone ingrowth, and a Bone Ingrowth Factor (BIF) was calculated as a percent. The light microscopic results showed BIFs of 4% at week 2, 47% at week 4, 62% at week 8, 84% at week 12, and greater than 90% at week 24. The SEM results showed BIFs of 5% at week 2, 34% at week 4, 69% at week 8, 75% at week 12, and in excess of 90% at week 24. The results of this study show that EDC implants are biocompatible and support rapid osseointegration in the rabbit tibia and suggest that, after additional studies, they may be suitable for use as dental implants in humans.

Alloys↗
PubMed1994

An evaluation of electrodischarged prototype implants in rabbit tibia: a preliminary study.

This is the first in a series of biological investigations using a porous implant fabricated by a novel process known as electrodischarge compaction (EDC). This process uses Ti-6A1-4V powder and electrical energy to construct a beaded porous implant without any compromise in physical characteristics, often found with conventional sintering. The purpose of this study was to evaluate the bone response in rabbit tibia of a porous titanium prototype implant fabricated by this new technique. One hundred forty-four porous EDC-fabricated implants were placed into the tibia of 36 New Zealand rabbits. Animals were placed into one of six time periods (2, 4, 8, 12, 18, and 24 weeks). At the appropriate time period, animals were killed, and bone ingrowth was evaluated qualitatively by light and scanning electron microscopy. Bone/implant interface bond strength was also measured. Slight bone ingrowth was observed as early as the two-week time period and increased in depth at each time period for the duration of the study. Implant/bone bond strength was measurable at four weeks and continued until reaching a plateau at week 12. The results of this study suggest that this novel EDC implant may be suitable for continued development of an easily fabricated, cost-effective dental implant.

Aluminum↗
PubMed1991

Intraoral sebaceous carcinoma.

An instance of sebaceous carcinoma that presented as a mass in the left buccal mucosa is described. This is the first known report in the English-language literature of a sebaceous carcinoma presenting as an intraoral tumor. The light and electron microscopic findings are described. The histologic differential diagnosis, clinical behavior, and appropriate therapy are discussed. Previously reported intraoral sebaceous neoplasms and sebaceous carcinomas of the parotid are reviewed.

Adenocarcinoma↗
PubMed1989

Benign solid oncocytoma of intraoral minor salivary glands.

We present an example of an intraoral benign solid oncocytoma of minor salivary gland origin. A review of intraoral benign solid oncocytomas reported in the English-language literature and discussion of the clinical behavior of these tumors are included.

Adenoma↗
PubMed1989

Verruciform xanthoma within carcinoma in situ.

This report describes an unusual case of verruciform xanthoma of the posterior floor of the mouth that occurred within carcinoma in situ. The significance of this case is described in light of current theories on the etiology and management of verruciform xanthoma.

Aged↗
PubMed1988

Dentinal candidiasis in cancer patients.

Two examples of an unusual presentation of oropharyngeal candidiasis in cancer patients are offered. The light and scanning electron microscopic appearances of candidiasis involving the dentin of teeth are described. The potential significance of recognition of this form of candidiasis in cancer patients is discussed.

Adenoma, Pleomorphic↗
PubMed1985

Megaloblastic anemia with oral lesions: a consequence of gastric bypass surgery.

This report describes the clinical and histologic features of a case of megaloblastic anemia, resulting from a gastric bypass operation, in which oral symptoms were the first significant finding. Although this case appears to be the first of its type reported in the literature, the potential for future cases is increasing with the increased use of the gastric bypass operation in the treatment of morbid obesity.

Adult↗
PubMed1983

Combined epithelial odontogenic tumor: adenomatoid odontogenic tumor and calcifying epithelial odontogenic tumor.

1. Two cases of a combined epithelial odontogenic tumor which had areas of AOT and CEOT were presented. 2. A review of the studies on histogenesis of the AOT revealed that the tumor probably consists of preameloblasts, stratum intermedium, and stellate reticulum. 3. A review of the studies on histogenesis of the CEOT revealed that the probable origin was in cells of stratum intermedium. 4. It is suggested that the present cases support the aforementioned theories of histogenesis and represent AOT's which contain foci of CEOT. 5. The suggested treatment is simple surgical excision.

Adolescent↗
PubMed1980

Acute recurrent gingivitis. A clinical entity.

A typical case of a previously undescribed form of gingivitis which is self-limiting and recurrent is discussed. The signs and symptoms include acute pain and swelling of interdental papillae with regional lymphadenopathy. As the disease progresses the localized swelling quickly spreads to the adjacent marginal and papillary gingiva. Ulceration is infrequent and without pseudomembrane formation or interdental cratering. We believe this to be a unique form of gingivitis and suggest the name acute recurrent gingivitis (ARG).

Acute Disease↗
PubMed1979

Blastomycosis with oral lesions. Report of two cases.

The recent literature suggests that blastomycosis (previously known as North American blastomycosis) with oral lesions may be more common than is generally realized. This report discusses two cases of blastomycosis in which oral lesions played a critical role in the ultimate diagnosis of the disease. The potential importance or oral lesions in early diagnosis and the necessity of culturing the organisms for definitive diagnosis are emphasized.

Adult↗
PubMed1978

Sialadenoma papilliferum of the oral cavity.

Sialadenoma papilliferum is a rare tumor of salivary gland origin. A review of the English-language literature indicates that only four cases have been reported. This article describes the clinical and histologic characteristics of an additional case occurring on the left retromolar pad.

Aged↗
PubMed1977

Intraoral melanocytic cellular nevi.

Eight cases of intraoral melanocytic cellular nevi are presented, together with the clinical features and limited follow-up information. These cases are added to those already published, so that a meaningful series may eventually be analyzed.

Adult↗
PubMed1976

Clinical and laboratory diagnosis of nutritional problems.

The objective of this article is to familiarize the dentist with clinical signs and laboratory methods used in diagnosing nutritional deficiencies, and to indicate which laboratory methods may be useful to the clinician in cases of suspected nutritional deficiency. It should be noted that the suggested laboratory methods were selected on the basis of their applicability for the clinical situation as well as their reliability as indicators of nutritional status. Therefore these suggested methods of choice may not in every instance be the most accurate of all indicators of nutritional status for a particular nutrient. The dentist who wishes to utilize one of the laboratory methods has a number of options. He can take the appropriate sample in his office, or refer the patient directly to a clinical laboratory for the simpler analyses, or refer his patient to a physician for appropriate metabolic testing. The first option may be more appropriate for the dentist practicing in areas where a clinical laboratory is not within reasonable distance. In this instance the dentist should contact the laboratory for specific information, such as sample volume and special instructions for taking, handling, and shipping the sample. The second option is available to the dentist practicing in an urban area where clinical laboratory facilities are readily available. Finally, the dentist should work in conjunction with a physician when complex metabolic testing is required.

Anthropometry↗