Biomedical subjects
Publications and source records attributed to J F Eastham.
An RF coil, made by twisting a conventional wire loop, was tuned to form an extended sensor to provide an effective method of showing the track of a catheter. A twisted-pair coil can be made small enough in diameter to pass through needles in common clinical use. The coil has a very small field of view and in transmit/receive operation has minimal effect on the magnetization of the surrounding tissue.
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We used quartz optical fibers and laser excitation in developing single-fiber fluoroprobes, to be used to measure molecular fluorescence in minute volumes of body fluids. We illustrate and discuss the analytical capabilities of these fluoroprobes. Limits of detection for the anti-tumor drug doxorubicin are about 10(-7) mol/L, by either conventional fluorescence or sequentially excited fluoroscence modes of detection. We also report the results of preliminary in vivo measurements of doxorubicin in the interstitial fluids of human tumors, heterotransplanted in immune-deficient laboratory mice.