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Biomedical subjects

J F Finucane

Publications and source records attributed to J F Finucane.

6 recordsLinked to original sources
PubMed1977

Effects of chronic renal disease on thyroid hormone metabolism.

Serum concentrations of total and free thyroxine and triiodothyronine together with urine losses of unconjugated thyroid hormones have been measured in normal subjects and in patients with renal disease. Serum total hormone values in the hypothyroid range were common the renal group and correlated inversely with the degree of renal impairment but not with renal loss of hormone which in the case of thyroxine exceeded the average normal daily loss ten-fold. The euthyroid state of patients with renal disease was best reflected by serum free thyroxine concentration which in every case was within the normal range. Poor correlation was apparent between the respective urine concentrations of albumin and thyroxine, and the reasons for this are discussed.

Adolescent↗
PubMed1976

Altered patterns of thyroid hormones in serum and urine in pregnancy and during oral contraceptive therapy.

Serum total, percentage free fraction and absolute serum free hormone concentration of thyroxine and triiodothyronine were measured in control, pregnant and oral contraceptive users, together with the daily urinary losses of unconjugated thyroid hormones. Increased urinary losses of both hormones, in particular thyroxine, were apparent in pregnancy and these could not be explained in terms either of an increased filtered load of hormone or the presence of proteinuria. The possible existence of filterable small-molecular weight hormone-binding substances in the urine of pregnant patients is discussed. It is concluded that assay of urinary thyroid hormones during pregnancy is of limited diagnostic value because of overlap with thyrotoxic values.

Adult↗
PubMed1975

Carbohydrate tolerance in autoimmune thyroiditis.

Glucose tolerance tests were carried out on fifty patients with autoimmune thyroiditis of varying duration and severity. Two were floridly diabetic, and a further six showed diabetic abnormalities of glucose tolerance, giving an over-all incidence of 16 per cent. Diabetics were significantly older than nondiabetics, but the two groups did not differ in terms of duration of thyroid disease or frequency of associated disease of probable autoimmune origin. The prevalence of diabetes in patients with autoimmune thyroiditis appears to be the same as that in the population generally.

Adult↗