PubMed Health⌕ Search

Biomedical subjects

J F García

Publications and source records attributed to J F García.

28 records · Page 2Linked to original sources
PubMed1990

[A clinical and biological study of 33 cases of polycythemia vera].

The clinical, analytical, evolutive and therapeutic aspects of 33 cases of polycythemia vera which were diagnosed according to the Polycythemia Vera Study Group criteria, are described. Mean age was 65 years with a slight predominance of females (54.5%). Hemorrhagic manifestations were the most frequent (67%) with a great number of patients with digestive manifestations consisting of GI hemorrhage, abdominal pain, portal or suprahepatic veins thrombosis. Splenomegaly was the most frequently found sign upon examination (73%). The mean hemoglobin leukocyte, and platelet levels were 18 g/dl, 16,000 mm3 and 738,000 mm3 respectively. It is note worthy the value of the erythropoietin for the differential diagnosis of secondary erythrocytosis as well as the value of the bone marrow histologic study which should be included in the diagnostic criteria of the disease. The evolution of the process is favorably altered by bleedings and chemotherapeutic cytoreduction which are often performed simultaneously.

Adult↗
PubMed1989

Exocrine pancreas in rabbits fed a copper-deficient diet: structural and functional studies.

The effects of a copper-deficient diet supplemented with D-penicillamine on both the structure and exocrine function of the pancreas were studied in rabbits. The pancreases of the animals kept on this diet for 13 weeks showed lesions in the acinar tissue but not in ductal or islet tissue. The weights of the glands were markedly reduced. Copper deficiency caused a slight (non-significant) reduction in the flow of pancreatic juice and in sodium output and significantly decreased chloride output (p less than 0.01). No changes were observed in bicarbonate and potassium output. Total protein and amylase secretions were maintained at clearly detectable levels in pancreatic juice, although they decreased significantly (p less than 0.01 and p less than 0.001, respectively), in the copper-deficient animals compared with the controls. The pancreases of the animals kept on a copper-deficient diet were seen to maintain their capacity for response to secretin, cholecystokinin (CCK), and bethanechol. Our results show that rabbit pancreatic acinar tissue is less sensitive to copper deficiency than that of other species studied. Additionally, the data on secretion of water and electrolytes suggest that in the rabbit the acinar cells may contribute to the secretory process with a chloride-rich fluid.

Amylases↗
PubMed1989

[A clinical and biological study of 11 cases of essential thrombocythemia].

11 patients diagnosed as suffering from essential thrombocytosis at "Hospital Xeral de Lugo" between 1978 and 1986, are presented. 7 patients were female and 4 were male with a median age of 63 years. 6 patients had thrombotic manifestation, 6 had hemorrhagic symptoms, 2 had both manifestations and only one had no thrombo-hemorrhagic clinical symptoms. Spleen enlargement was found in 6 cases and liver enlargement in 5. The median count of platelets were 1.585.000 ml; there was no relationship between the amount and their function with the major or minor complications incidence. There was a good response to treatment with hydroxyurea and/or busulfan associated to platelets aggregation inhibitor in some cases. 4 patients died, all of them due to thrombotic complications.

Adult↗
PubMed1989

[Urinary tract infections in primary care: predominant microbes and their antibiotic sensitivity].

We have prospectively evaluated 227 episodes of community-acquired urinary tract infection (UTI) from October 1st to December, 15th, 1987. The urine samples, adequately collected, were processed in the Bacteriology Laboratory of the Albacete General Hospital. E. coli was the most commonly isolated organism (62%), followed by Proteus mirabilis (6.6%), Streptococcus faecalis (6.6%), Serratia marcescens (6.6%) and Klebsiella pneumoniae (6.2%). As regards the sensitivity of E. coli to the most commonly used antibiotics, there was a 56% resistance to ampicillin, 37% to cotrimoxazole, 40% to amoxycillin/clavulanic acid, and 46% to cephalothin. These are in contrast with the small number of resistance, at least in vitro, to urinary chemotherapeuticals and phosphomycin. We emphasize the importance of the knowledge of the organisms more commonly involved in UTI and their updated sensitivity to antimicrobials for the best management of these infections.

Ampicillin Resistance↗
PubMedDate not supplied

Reusability of plastic scintillators used in beta emitter activity determination.

The use of plastic scintillation in the measurement of beta emitter activity is a suitable alternative to classical detection techniques in spite of the high cost and potential memory effects. Reuse of the plastic scintillator beads after a cleanup procedure would overcome both drawbacks. In the present paper, we tested several cleaning solutions (water, HCl 0.1M, commercial soap, EDTA 0.01 M pH=3, citric acid 0.1 M pH=3). The recommended procedure consists of the immersion of the beads in three consecutive citric acid baths for 24 h. If this protocol is followed, plastic beads contaminated with 90Sr/90Y, 14C, and 3H recover their initial condition, and can be used in successive determinations.

Beta Particles↗
PubMedDate not supplied

[What is the cost of inappropriate admission of pneumonia patients?].

BACKGROUND: The number of patients admitted with community-acquired pneumonia (CAP) varies greatly from one hospital to another. Prognostic models for CAP can help physicians decide which cases to treat on an outpatient basis. Our aims were: a) to validate a model for predicting low-risk CAP, and b) to estimate savings that would have resulted if the low-risk patients identified by the model had been treated at home rather than in hospital. PATIENTS AND METHODS: All CAP cases diagnosed by the emergency room physicians of a hospital in northwestern Spain (Ferrol) were enrolled prospectively over a period of 19 months. The prediction rule of Fine et al was used to classify all patients. Mortality in each category was compared with the mortality predicted by Fine's system. Patients in the lowest risk categories (I and II) were considered to have been inappropriately admitted unless they were hypoxemic or had significant comorbidity. Costs were figured based on data provided by our accounting department. RESULTS: Of 192 CAP patients enrolled, 131 were admitted and 61 were treated as outpatients. Ten patients died, none of whom was in classes I or II. The costs of the apparently unnecessary hospital stays of the 34 patients in these classes was 6,979,756 pesetas. The estimated savings that would have derived from treating these patients out-of-hospital was 6,133,292 pesetas (36,862 euros; 322,804 pesetas/month). CONCLUSIONS: a) The predictive model used has been found useful for identifying patients at very low risk of dying from CAP; b) Using this model can improve CAP admission criteria, and c) Application of the model can lead to savings.

Community-Acquired Infections↗