Biomedical subjects
Publications and source records attributed to J F Garvey.
A case of fibrous histiocytoma of low grade malignancy arising from the uncinate lobe of the pancreas is reported. This is an unusual site for these extremely rare tumours. Survival up to 4 years has been achieved in our patient following surgical resection.
This study examines the endocrine function of duct-obliterated canine segmental autografts for periods up to 5 years posttransplant. Overall the response profile of autografted animals was subnormal. After intravenous glucose tolerance tests K-values in transplanted animals (2.8 +/- 0.9%/min) were significantly lower than normal (4.6 +/- 1.2% min, p less than 0.001). After oral glucose stimulation, blood glucose in the autografted dogs reached a mean peak of 10.6 +/- 2.8 mmol/L whereas in normal dogs the peak value was 6.0 +/- 1.0 mmol/L (p less than 0.002). The mean insulin response in autografted dogs showed lower insulin concentrations in the early stages of the test, whereas insulin secretion after glucagon stimulation was significantly reduced in autografted dogs. Intravenous glucose tolerance tests were analyzed by calculating K value or measuring a single blood glucose concentration 40 min after glucose injection. This value had a high correlation with the K value (r = 0.967). No progressive deterioration of graft function up to 5 years was found. Glycosylated hemoglobin levels were measured in autografted (646 +/- 59 pmol/mg) and normal dogs (620 +/- 85 pmol/mg) and no significant difference was found. In conclusion, duct-occluded segmental pancreatic autografts were shown to have a reduced functional capacity but there was no deterioration of function up to 5 years after duct-occlusion and grafting. The degree of metabolic control may be sufficient to prevent diabetic complications.
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Pancreata from 17-18-day gestational rat embryos have been transplanted between related and unrelated adult rats rendered diabetic with streptozotocin. In separate experiments allograft recipients were given the immunosuppressive agent cyclosporin A. The morphologic changes in most of these grafts were followed during the first 2 weeks after transplantation. The endocrine, but not the exocrine, tissue developed fully in the isografts and did so at a rate corresponding to that reported for in vitro cultures. Within the allografted pancreata there was no maturation of the exocrine components, and endocrine tissue only reached full maturity if immunosuppression was used. Allograft rejection was similar morphologically to that of other tissues, involving cellular and humoral factors. The cells within the graft evoking rejection were not identified. These studies indicate that if rejection could be adequately suppressed, the endocrine parts of the fetal pancreas would survive and develop.
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A study of the performance of the first Wyndham Scheme students in the Faculty of Medicine at the University of New South Wales was undertaken. Forty-five percent of the cohort of 237 graduated in the minimum time, and 76% eventually graduated in succeeding years. Of the 130 entrants with Higher School Certificate (HSC) aggregates of 500+, 60% graduated in minimum time; in the case of the 107 entrants with HSC aggregates of less than 500, the figure was 28%. There was an extremely high correlation rate (r = 0.98) between HSC aggregate and success in the course at the first attempt. There was no significant difference between the minimum time or eventual graduation rates of males (211) and females (26), despite the fact that females had a significantly higher performance in the HSC; There was no improvement in the numbers graduating in the minimum time compared with the first intake of medical students at the University of New South Wales, or the last "pre-Wyndham" intake. A comment about wastage rates is made and suggestions for remedying the situation are put forth.