Biomedical subjects

J F Geddes

Publications and source records attributed to J F Geddes.

58 records · Page 4Linked to original sources

PubMedDate not supplied

Violence is not necessary to produce subdural and retinal haemorrhage: a reply to Punt et al.

In this article we reply to the recent critique by Punt et al. in Pediatric Rehabilitation. Our hypothesis about the pathogenesis of intracranial bleeding in infants has three important implications. First, in the case of an infant with a swollen brain, subdural and retinal haemorrhage but no objective evidence of trauma, the findings by themselves are not certain evidence of abuse; second, violence is not necessary to produce subdural and retinal haemorrhage; and lastly, non-traumatic events producing apnoea with a catastrophic rise in intracranial pressure could produce a clinical picture identical to that seen in trauma.

Brain Hemorrhage, Traumatic↗

PubMedDate not supplied

Symmetrical columnar necrosis of the basal ganglia and brain stem in an adult following cardiac arrest.

Prolonged cardiac arrest resulting from a methadone overdose in an adult produced an unusual pattern of symmetrical columnar necrosis of the diencephalon and the brain stem tegmentum. This pattern of anoxic encephalopathy has previously been described in neonates, infants and in one adult case. Our description of a further case underlines the fact that under exceptional circumstances it may also occur in adults.

Adult↗

PubMedDate not supplied

Juvenile parkinsonism caused by chronic meningoencephalitis: a clinicopathological study.

After a six-year history of poor concentration, intellectual and growth retardation, and a one-year history of absences, an 11-year-old girl developed parkinsonism and thereafter had a progressive, predominantly extrapyramidal disorder for the next nine years, until her death at age 20. Other clinical features included pyramidal signs, peripheral neuropathy and sideroblastic anemia. Despite a clinical course suggestive of a degenerative condition, the principal findings on examination of the brain were chronic meningitis, brainstem encephalitis and mild diffuse cerebral gliosis. Extensive investigations failed to demonstrate an infective agent, either in life or by post mortem examination.

Adult↗

PubMedDate not supplied

Mixed cranial nerve tumors in neurofibromatosis type 2.

Five cerebellopontine angle tumors from four patients with neurofibromatosis (NF) are described. Three were surgical resection specimens from patients with NF2 and two were removed at autopsy from a fourth patient who appears to have had a variant of NF2. On microscopy the three biopsy specimens appeared to be histologically mixed tumors: although they were predominantly typical benign schwannomas, the tumors also contained islands of meningioma, the two tumor types being closely intermingled. In our fourth patient, consecutive decalcified sections of the tumors in the petrous temporal bones revealed florid arachnoidal proliferation around both schwannomas. This had resulted in the formation of multiple "micromeningiomas", some of which had become partially incorporated into the tumor. There are a few previously reported examples of mixed schwannoma-meningiomas in the literature. Possible mechanisms for such a mixed tumor are discussed: the most likely explanation for the appearances in cases of apparently mixed vestibular nerve tumors is that reactive meningeal changes adjacent to the tumor are responsible. Arachnoidal proliferation appears to be more exuberant in bilateral acoustic neurofibromatosis than in sporadic acoustic schwannomas, possibly the result of a disease-related growth factor.

Adult↗