Mutagenicity of some fluoro-derivatives of benzo[alpha]pyrene.
Benzo[alpha]pyrene (BP) and its 4 fluoroderivatives substituted at positions 7(BP-7F), 8(BP-8F), 9(BP-9F) and 10 (BP-10F) were mutagenic in strains TA98 and TA1538 of Salmonella typhimurium, when tested in the presence of liver S-9 or microsomes from Aroclor or 3MC-treated rats. While the presence of fluorine at position 10 resulted in some reduction in mutagenicity, several-fold increase in mutagenicity occurred when fluorine was substituted at position 8. Our data suggests additional involvement of other metabolites in the mutagenicity of BP.
Animals↗