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Biomedical subjects

J F Gonnet

Publications and source records attributed to J F Gonnet.

7 recordsLinked to original sources
PubMed2000

"Cyclamen Red" colors based on a macrocyclic anthocyanin in carnation flowers.

The "cyclamen" red (or pink) colors in carnation flowers-cultivars Red Rox and eight others-are based on the presence of a new macrocyclic anthocyanin, pelargonidin 3,5-di-O-beta-glucoside(6' ', 6' "-malyl diester) identified by spectroscopic methods. The instability of the bridging malyl group with sugars in acidic medium readily causes the formation of the opened ring form, 3-O-(6' '-O-malylglucoside)-5-O-glucoside. The issue of cyclamen colors based in carnations on this original acylated pelargonidin derivative simulating those based on simpler cyanidin glycosides in Rosa cultivars is discussed using CIELAB colorimetric coordinates.

Anthocyanins↗
PubMed1983

Comparative study of methods chosen by the Association Française de Normalisation (AFNOR) for evaluating sensitizing potential in the albino guinea-pig.

An evaluation was made of the different protocols recommended by the Association Française de Normalisation (AFNOR) for assessing the sensitizing potential of chemicals in the guinea-pig. The methods studied were those of Magnusson & Kligman (J. invest. Derm. 1969, 52, 268), Maguire (J. Soc. cosmet. Chem. 1973, 24, 151), Maurer et al. (Agents & Actions 1975, 5, 174), Klecak et al. (J. Soc. cosmet. Chem. 1977, 28, 53), Dossou & Sicard (1984, to be published) and a hitherto unpublished method of Guillot, Gonnet, Clément & Brulos. Results obtained by each method were compared in tests on the allergenic reference substances dihydrocoumarin, p-phenylenediamine, formalin, penicillin G and benzocaine (ethoform) and on propylene glycol (negative control). The results showed that the number of animals sensitized often varies with the choice of experimental protocol, that inclusion of tests on a control substance is essential, and that while quantitative differences were found, the methods were qualitatively similar in their capacity to identify allergens in the guinea-pig.

Animals↗
PubMed1982

Evaluation of the cutaneous-irritation potential of 56 compounds.

The primary cutaneous irritation of 56 chemicals was tested in the rabbit using three different procedures. The three protocols selected for the tests were the method published by the French authorities for the testing of cosmetics and toiletries (Journal Officiel 21 April 1973, p. 3862; ibid 5 June 1973, p. 3953) and the methods proposed for the testing of chemicals by the Association Française de Normalisation (AFNOR) and, in 1979, by the Organisation for Economic Co-operation and Development. The results of the three sets of tests were compared and the effects of differences in procedure and numbers of animals were studied, together with the possible relation between irritancy and the pH of the test material. It was concluded that the AFNOR protocol best met the requirements for such tests and that gloves should be worn for the handling of all substances classified as moderately or severely irritant on that scale.

Animals↗
PubMed1982

Evaluation of the ocular-irritation potential of 56 compounds.

The ocular irritancy of 56 chemicals was tested in the rabbit eye, with and without rinsing, using a procedure that complied with the main requirements of three protocols, namely those proposed by the Association Française de Normalisation (AFNOR) in 1982 and by the Organisation for Economic Co-operation and Development in 1979 for the testing of chemicals and that published by the French authorities (Journal Officiel 21 April 1971, p. 3862; ibid 5 June 1973, p. 3953) for the testing of cosmetics and toiletries. The results obtained were used to establish the extent to which the assessment of a chemical's irritation potential was affected by the differences between the three protocols in respect of the observation times prescribed, the inclusion and timing of rinsing, the number of animals used and the interpretation procedure. Conclusions were also drawn about the influence of the physical state and pH of a material on its potential irritancy and about the level of irritancy that necessitates the use of eye protection.

Animals↗