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Biomedical subjects

J F Gurry

Publications and source records attributed to J F Gurry.

8 recordsLinked to original sources

Abdominal aortic aneurysms: recent experience with 210 patients.

In the 6 1/2 years ending June 1977, 210 patients with abdominal aortic aneurysms underwent operation at Toronto Western Hospital; 160 aneurysms (76%) were unruptured and 50 (24%) were ruptured. In the patients with unruptured aneurysms the mean age was 68 years; the oldest was 91, and 12 were more than 80 years of age. The overall hospital mortality was 5.6%. Death in hospital occurred in 1 (1.2%) of the 83 asymptomatic patients, 4 (7.4%) of the 54 symptomatic patients and 4 (17.0%) of the 23 patients for whom operation was considered urgent. In the patients with ruptured aneurysms the mean age was 71 years; the oldest was 90, and five were more than 80 years of age. The overall hospital mortality was 54%. The morbidity and mortality were analysed; in particular the reasons for the markedly variable hazard of operations for the three categories of unruptured aneurysm were sought. The surgical literature is confusing because of the interchanging use of the words unruptured, elective and symptomless. The current philosophy management and technique of operation in a large cardiovascular surgery service with many trainees are presented and a plea is made for a standardized and simplified operation, always performed with three assistants helping the operating surgeon.

Aged

Arteriosclerotic femoral artery aneurysms.

Arteriosclerotic aneurysms of the femoral artery are uncommon lesions that occur in elderly men. In 30 patients 36 aneurysms were repaired at the Toronto Western Hospital from January 1965 to June 1977. Half of the patients presented with ischemia and one quarter with an enlarging mass, and one quarter had no symptoms. Two thirds had other aneurysms and one third had suffered from cerebral or myocardial ischemia. The technique of repair changed from reconstructive aneurysmorrhaphy before 1970 to use of an interposition arterial prosthesis thereafter. Minimal groin dissection, internal control of blood flow in the deep femoral artery, and use of an appropriate arterial prosthesis provided excellent results. Surgical repair is recommended for most symptomatic ones when the patient's life expectancy is more than 2 years.

Aged

A controlled trial of intraperitoneal noxytiolin in perforated appendicitis.

A controlled trial of intraperitoneal noxytiolin (Noxiflex) solution in patients with peritonitis due to perforated appendicitis is reported. No significant difference was found in the incidence of complications between the treated and a control group, raising doubts as to whether this substance is of value when used intraperitoneally in peritonitis.

Administration, Topical

An elemental diet as preoperative preparation of the colon.

In a study comparing patients prepared for colonic surgery with an elemental diet (Vivonex) with a control group there was no significant difference in incidence of wound infection or other complications between groups. Furthermore, there was no change in the population levels of the colonic microflora nor were the numbers of species decreased after 2-4 days on the diet. Although in most cases aiding in the mechanical preparation of the colon, the elemental diet has not been shown to confer any other advantage.

Aged

A rabbit model of perforated appendicitis with peritonitis.

No satisfactory animal model simulating acute perforating appendicitis followed by peritonitis in man has hitherto been achieved. A technique has been developed in New Zealand White rabbits to fulfil these desiderata. The bacterial flora associated with the ensuing peritonitis is similar to that found in man both as regards aerobes and anaerobes and their concentrations. The method effectively produces the required model in 70 per cent of rabbits subjected to the experiment. Satisfactory postoperative survival is achieved enabling therapeutic studies.

Animals

The effect of noxytiolin in experimental peritonitis.

The evidence for the value of noxytiolin (Noxyflex) in peritonitis is contradictory. In a controlled trial of the effect of noxytiolin in pertonitis in rabbits we have found a significant increase in mortality in the trial group compared with a control group, but no significant difference when a dose equivalent to the recommended human dose is used. The postoperative course is adversely affected in the animals receiving noxytiolin.

Animals