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Biomedical subjects

J F Gwynne

Publications and source records attributed to J F Gwynne.

At least 19 recordsLinked to original sources
PubMed1986

Campylobacter-like organisms in gastric biopsies: a Christchurch study.

Following a 20 patient pilot investigation for Campylobacter pyloridis in selected gastric biopsy specimens, 56 consecutive patients subjected to routine gastroscopies were further examined. 14/56 had positive gram stains for spiral gram negative bacilli in gastric biopsy imprints and 4/14 had positive culture for this organism. All 14 positive specimens showed histological gastritis of varying degrees (grade 3 inflammation). The methodology, significance and implications of these findings are discussed in this first New Zealand report of C pyloridis in the stomach.

Adult↗
PubMed1983

Sudden cardiac death in Otago: a review of 408 cases.

Four hundred and eight sudden cardiac deaths are reviewed from epidemiological and pathological viewpoints. All cases were investigated by Otago coroners between 1971 and 1979. Necropsies were performed personally by the author, these representing over 80% of such examinations in the specified period. Fifty-four point nine percent of the deaths occurred at home, 9.1% in public places, 9.1% in hospitals and 3.7% in sports grounds. The majority (88.7%) occurred between the ages 41-80, the peak being 51-70 (61.3%). Seventy-one point three percent were male. There was an associated history of physical exertion in 19.4% but relevant information was unobtainable in 46.6%. Judging from gastric contents, food had been consumed recently in 64.9%. There was a relevant medical history in 44.6%. In 40.9% significant symptoms were recorded prior to the deaths. At necropsy 84.8% were attributed to ischaemic heart disease, 7.1% to myocarditis, 4.7% to cardiomyopathy and 3.4% to valvular disease.

Adolescent↗
PubMed1983

Cirrhosis of the liver following therapy with perhexiline maleate.

Two patients developed cirrhosis of the liver following therapy with perhexiline maleate. Liver failure and polyneuropathy caused death in one patient who had received 300 mg daily for three years. Cirrhosis was an unexpected finding in the other patient whose perhexiline dose was 200 mg daily for five years. Perhexiline should be prescribed cautiously and discontinued if liver function tests become abnormal. Monitoring of blood levels may lead to a reduction of toxicity.

Humans↗
PubMed1981

Sudden death from occlusive disease of the atrioventricular node artery.

Non-atherosclerotic focal occlusive disease of the atrioventricular node artery was the only significant pathological lesion found at autopsy in 2 individuals aged 40 and 17 yr who died suddenly and unexpectedly. The cases were observed amongst 115 autopsies categorized as sudden cardiac death and performed during an 18 mth period. Occlusive disease of the atrioventricular node artery is a poorly documented entity of unknown aetiology and pathogenesis. We believe it is a more frequent pathological finding in sudden cardiac death than has been previously recognized and that it deserves more attention than it currently receives.

Adolescent↗
PubMed1980

Alcoholism and mortality in Otago.

A series of 1574 coroner's necropsies in Otago have been reviewed from the point of view of alcohol involvement. Alcohol was found to be a significant factor in 12.2 percent of the total and 32.1 percent of the unnatural deaths over the age of 15.

Accidents, Traffic↗
PubMed1978

Bilateral internal carotid artery thrombosis after closed head injury.

A case of bilateral internal carotid artery thrombosis after blunt injury to the head in a 54 years old male is described. The literature is reviewed and comment is made on the causes. Unilateral thrombosis of the internal carotid artery after closed or blunt injury to the head and neck is well known but not common. There is only one previously recorded case of bilateral internal carotid artery thrombosis after such an injury (Yashon et al. 1964).

Carotid Artery Diseases↗
PubMed1977

Death certification in Dunedin hospitals.

An analysis is presented of death certification in Dunedin Hospitals. The study involved a comparison of death certificates with post-mortem findings in 643 deaths which occurred in Dunedin hospitals between 1 October 1971 and 30 September 1973. The cases were categorised according to diseases in the various body systems. The study also involved consideration of the format of the current death certificate and of attitudes towards death certification. Serious defects have been revealed in all areas of the study which are considered to be representative of the national scene. Errors of epidemiological significance were found in 64.7 percent of the certificates, and in 57.5 percent of individual diagnoses. Responsibility for the defects lies with the certification itself and not with the statisticians who diligently compile mortality data from the information supplied to them.

Autopsy↗
PubMed1977

Fatal road accidents in Otago.

Fatal road accidents which have occurred in Otago between 1971 and 1975 have been studied. The series represents approximately 5% of the national toll. The main purpose of the study has been to analyse background data with a view to discovering causative factors leading to prevention. The study confirms the importance of alcohol, low seat-belt usage, speed, and youth as significant factors. The importance of the driver environment is also highlighted. The analysis shows a low incidence of alcohol among motor cyclists. There were a significant number of pre-school age pedestrian deaths in the series. Only six cyclists were killed in the five-year period.

Accidents, Traffic↗