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Biomedical subjects

J F Hermanns

Publications and source records attributed to J F Hermanns.

11 recordsLinked to original sources

[Immunohistochemistry of Borrelia type spirochetes].

We have looked for the presence of Borrelias by immunohistochemistry in cutaneous biopsies taken from patients with positive Borrelia serology. We used the monoclonal antibody "P41 Borrelia burgdorferi flagellin". We found Borrelias in the dermis of Pick-Herxheimer disease (3/3), erythema chronicum migrans (6/9), lymphocytoma (1/3), and morpheas (2/5). They were also seen in the vascular wall of hypodermal arterioles in a case of cutaneous periarteritis nodosa (1/2). Treponema pallidum was not revealed by the antibody.

Antibodies, Monoclonal

[Scabies].

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Europe

Morphometric study of cauliflower collagen fibrils in dermatosparaxis of the calves.

The abnormal cauliflower collagen fibrils present in the skin of dermatosparactic calves were studied by electron microscopy and computerized image analysis. The structure of the fibrils is heterogeneous and varies according to their location in the dermis. Cauliflower fibrils seems due to a defect in the lateral cohesion between the constitutive procollagen polymers. This is associated with the presence of a non-collageneous material larger than the aminopropeptide surrounding the procollagen polymers, while the volume occupied by procollagen in each fibril is comparable to that of collagen in normal fibrils.

Animals

Immune complex disease associated with Peroben intake.

The clinical history and biological investigations of a patient presenting an immune complex disease induced by Peroben are reported. Biological signs were those of a drug-induced lupus syndrome. A provocation test allowed disclosure of its pathomechanism, since during Peroben intake a high C1q binding activity occurred and later regressed, while deposits of IgM and C3 were evidenced in the vessel walls. Complete or partial thrombosis succeeded accompanying a leukocytoclastic vasculitis.

Adult

[Bullous skin diseases].

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Diagnosis, Differential