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Biomedical subjects

J F Jiménez

Publications and source records attributed to J F Jiménez.

At least 19 recordsLinked to original sources
PubMed2002

Genetic variability in a narrow endemic snapdragon (Antirrhinum subbaeticum, Scrophulariaceae) using RAPD markers.

Antirrhinum subbaeticum is an endangered species inhabiting fragmented limestone cliffs. In the last 3 years, a drastic population decline has been observed in three of four known populations and the estimated number of surviving individuals is now close to 400. A RAPD study was conducted to evaluate the levels of genetic variation present in this species to improve conservation guidelines. Thirty-nine polymorphic products identified 66.1% of the samples by unique RAPD multilocus profiles. A cluster analysis grouped the samples into two broad groups corresponding to northern or southern provenances. AMOVA analysis showed that only 17.7% of the genetic diversity was partitioned within populations. These results are in contrast to data available for other Antirrhinum species. This genetic structure could be explained by the predominant selfing behaviour exhibited by A. subbaeticum as opposed to the allogamy of other congeners. Genetic diversity within populations does not seem to be strongly related to population size and historical factors could be responsible for the very low levels of genetic diversity found in one population. Given the low genetic diversity within populations, it is suggested that an extensive sampling of individuals be made for recovering appropriate levels of the gene pool for ex situ preservation. However, translocation of individuals to the genetically weakened Bogarra population from other sources is not recommended.

Antirrhinum↗
PubMed1990

[Contribution of echography to the study of the andrologic patient].

Our experience in the ultrasonographic evaluation of the prostate and seminal vesicles in prostatitis and male infertility are reported herein. In our view, this noninvasive imaging technique must be performed before recurring to other methods that involve manipulation. Similarly, we discuss the possibilities of duplex Doppler in the diagnosis of vascular disorders in the male consulting for impotence. We believe this simple noninvasive imaging technique can significantly reduce the number of patients that may require cavernosometry and cavernosography.

Erectile Dysfunction↗
PubMed1986

Crossed chemoprophylaxis assay between adriamycin and cis-platinum in recurrent superficial bladder tumor.

Of 146 patients with superficial bladder carcinoma, 66 (35 primary and 31 recurrent from failure of thiotepa chemoprophylaxis) relapsed following transurethral resection (TUR) and chemotherapy with adriamycin or cis-platinum. A new TUR was carried out. In case of progression in the number of tumors, size, stage or grade, treatment was begun with the other drug. If the tumor had the same characteristics, treatment was continued with the same drug. In both the primary and recurrent tumors with or without progression, cis-platinum controlled the tumor better than adriamycin, rescuing it from the latter and obtaining a recurrence index and disease-free interval as with cis-platinum alone. These results are more conclusive in primary tumors.

Cisplatin↗
PubMed1985

Thiotepa versus adriamycin versus cis-platinum in the intravesical prophylaxis of superficial bladder tumors.

A study was performed on 184 patients with superficial bladder cancer (pTa, pT1), 92 with primary and 92 recurrent tumors. After TUR of all visible lesions, endovesical chemotherapy with thiotepa, adriamycin or cis-platinum was started on the 15th and 30th days following surgery. There were no statistically significant differences between any of the three chemotherapies at the doses and intervals mentioned. Only cis-platinum has proven to be more effective in primary high grade tumor.

Cisplatin↗
PubMed1985

Urinary lipids in vesical carcinoma: a new biological marker. Preliminary study.

We have determined urinary lipids by thin-layer chromatography in 40 patients with bladder tumors, and have evaluated their modification following tumor removal and their predictive value in terms of the presence or absence of recurrences. The results obtained were compared with those of a control group without tumoral pathology (14 patients) and 11 cases with bacterial infection of the urinary tract. There is a marked difference between the lipidogram of the tumoral group of patients and the controls (p less than 0.005), especially in the phospholipid to fatty acid (PL/FA) relationship, with a specificity of 100% and a sensitivity of 80%. With regard to recurrences, in non-recurrent cases the PL/FA value remained high in relation to the initial value (p less than 0.005), whereas in the recurrent cases the value rose to 'tumoral limits'. Macrohematuria and urinary infection modify the lipidogram, resulting in values similar to the tumoral cases. Their absence is therefore essential in order to evaluate the results. The urinary lipidogram appears to be a possible biological marker for bladder tumors.

Chromatography, Thin Layer↗
PubMed1980

[Allopurinol in progressive muscular dystrophy (author's transl)].

Authors have treated with allopurinol ten children with progressive muscular dystrophy, whose ages were between 15 months to eleven years. An initial and monthly clinical evaluation of muscular strength, Gowers's sign and pseudohypertrophy was performed. Monthly determinations of CPK, LDH, aldolase, GOT and serum urate; every two months electromyography was also made. In three patients a complete recovery of strength, Gowers's sign was found and at the same time pseudohypertrophy diminished; the age average was three years and four months. In four patients a partial recovery was found; the age average was nine years and four months. In three patients there was no answer to treatment, they were contracted and had deformities, being age average ten years. No variations on monthly controls of CPK, LDH, aldolase and GOT were observed. On these facts their opinion is that allopurinol is an effective drug in the treatment of progressive muscular dystrophy and that its' effectivity is better when treatment is initiated early and, of course, before patients present deformities and contractures.

Allopurinol↗
PubMedDate not supplied

[Dimethyl sulfoxide in the treatment of interstitial cystitis].

The paper presents the results obtained with endovesical dimethylsulphoxide in the treatment of interstitial cystitis in 30 women. Up to 80% patients showed clinical improvement with an average of 10 installations. Volume of maximal vesical capacity was increased in 24 patients (80%), the increase being greater than 100 cc in 10 cases. Presently, 24 (80%) patients remain under treatment, 14 with one instillation monthly and 10 once every six months. Six patients are fully asymptomatic without treatment after an average symptoms-free interval of 32 months. Since this is directly related to a decrease both in pain and miction frequency, the increase in vesical capacity appears to be a good improvement index. Dimethylsulphoxide in neither a healing nor a definite therapy but it seems to be effective in the management of this unknown disease.

Administration, Intravesical↗
PubMedDate not supplied

[Directed chemotherapy in superficial carcinoma of the bladder conditioned by the knowledge of recurrence factors].

A retrospective study of 56 patients (23 primary and 36 relapsing) with superficial vesical carcinoma and treated with transurethral resection and directed chemoprophylaxis was done. Directed chemoprophylaxis is define as a specific type of adjuvant therapy where the drug is determined by a previous study with multivariant analysis of the relapse risk factors of a group of 385 cases, where the chemotherapeutic agent was also a variable. The drug is specified by the data introduced in a microprocessor program. Such chemoprophylactic approach has achieved a marked reduction in the relapse rate and increased the disease-free interval from 8 to 3 and from 70 to 83.5 respectively, with regard to the free drug choice approach.

Antineoplastic Combined Chemotherapy Protocols↗